ID G1RFB7_NOMLE Unreviewed; 1020 AA.
AC G1RFB7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Family with sequence similarity 13 member A {ECO:0000313|Ensembl:ENSNLEP00000011917.1};
GN Name=FAM13A {ECO:0000313|Ensembl:ENSNLEP00000011917.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000011917.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000011917.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000011917.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FAM13 family.
CC {ECO:0000256|ARBA:ARBA00007549}.
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DR EMBL; ADFV01030602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01030603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01030604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01030605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01030606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01030607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01030608; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01030609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01030610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01030611; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012354923.1; XM_012499469.1.
DR AlphaFoldDB; G1RFB7; -.
DR STRING; 61853.ENSNLEP00000011917; -.
DR Ensembl; ENSNLET00000012499.2; ENSNLEP00000011917.1; ENSNLEG00000009768.2.
DR eggNOG; KOG4270; Eukaryota.
DR GeneTree; ENSGT00950000183033; -.
DR HOGENOM; CLU_012606_1_0_1; -.
DR InParanoid; G1RFB7; -.
DR OMA; ETHYCLL; -.
DR TreeFam; TF328895; -.
DR Proteomes; UP000001073; Chromosome 9.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04393; RhoGAP_FAM13A1a; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR039102; FAM13.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15904; FAM13; 1.
DR PANTHER; PTHR15904:SF18; PROTEIN FAM13A; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 43..231
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 267..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 723..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 945..972
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 378..403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..474
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..521
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1020 AA; 116553 MW; 7F6CCEC367AE62BD CRC64;
MGAGALAICQ SKAAVRLKED MKKIVAVPLN EQKDFTYQKL FGVSLQELQR QGLTENGIPA
VVWNIVEYLT QHGLTQEGLF RVNGNVKVVE QLRLKFESGV PVELGKDGDV CSAASLLKLF
LRELPDSLIT SALQPRFIQL FQDGRNDVQE NSLRDLIEEL PDTHYCLLKY LCQFLTKVAK
HHVQNRMNVH NLATVFGPNC FHVPPGLEGM KKQDLCNKIM AKILENYNTL FEVEYTENDH
LRCENLARLI IVKEACYKNI LLTRGLERDM PKPPPKTKIP KSRSEGSIQA HRVLQPELSD
GIPKLSLRLS HRKSCLEDMN SAEDAISAKL VPSSQEDERP LSPFYLSAHV PQVSNVSATG
ELLERTIRSA VEQHLFDVNN SGGQSSEDSE SGTPSASSAT SARQRRRQSK EQDEVRRGRD
KGLTNKENIP SGFNHLDDCI LNTQEVEKVH ENTSGCAGER SKPKRQKSST KFSELHDNQD
GLVNMESLDS TRSHERTGPD DFERMSDERK GNEKDGGHTQ HFESPTMKIQ EHPSLSDTKQ
QRNQDAGDQE ESFVSEVPQL DLTALCDEKN WEEPAPAFSS WQRENSDSDE AHLSPQAGRL
IRQLLDEDSD PMLSPRFYAY GQSRQYLDDT EVPPSPPNSH SFMRRRSSSL GSYDDEQEDL
TPAQLTRRIQ SLKKKIRKFE DRFEEEKKYR PSHSDKAANP EVLKWTNDLA KFRRQLKESK
LKISEEDLTP RMRQRSNTLP KSFGSQLEKE DEKKQELVDK AIKPSVEATL ESIQRKLQEK
RAESSRPEDI KDMTKDQIAN EKVALQKALL YYESIHGRPV TKNERQVMKP LYDRYRLVKQ
ILSRANTIPI IGSPSSKRRS PLLQPIIEGE TASFFKEIKE EEEGSEDDSN VKPDFMVTLK
TDFSARCFLD QFEDDADGFI SPMDDKIPSK CSQDTGLSNL HAASIPELLE HLQEMREEKK
RIRKKLRDFE DNFFRQNGRN VQKEDRTPMA EEYSEYKHIK AKLRLLEVLI SKRDTDSKSM
//
