ID G1RGL7_NOMLE Unreviewed; 1329 AA.
AC G1RGL7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
GN Name=CIITA {ECO:0000313|Ensembl:ENSNLEP00000012367.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000012367.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000012367.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000012367.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01049115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 61853.ENSNLEP00000012367; -.
DR Ensembl; ENSNLET00000012968.2; ENSNLEP00000012367.2; ENSNLEG00000010140.2.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000161578; -.
DR HOGENOM; CLU_010691_1_0_1; -.
DR InParanoid; G1RGL7; -.
DR OMA; PFAFPRH; -.
DR TreeFam; TF352118; -.
DR Proteomes; UP000001073; Chromosome 18.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0034341; P:response to type II interferon; IEA:Ensembl.
DR CDD; cd00116; LRR_RI; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR008095; MHC_II_transact.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47189; MHC CLASS II TRANSACTIVATOR; 1.
DR PANTHER; PTHR47189:SF1; MHC CLASS II TRANSACTIVATOR; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR PRINTS; PR01719; MHCIIACTVATR.
DR SMART; SM00368; LRR_RI; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 415..725
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 155..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1329 AA; 144859 MW; 14CF6242FCA8F6E0 CRC64;
MRCLAPHPAG SYLSEPQGSS QCATMELGPL EGGYLELLNS DADPLCLYHF YDQMDLAGEA
EIELYSEPDT DTINCDQFSR LLSDMEGDEE TREAYANIAE LDQYVFQDSQ LEGLSKDIFI
EHIGPDEVIG ESMEMPAEVG QKSQKRPFPE ELPADLKHRK PAEPPTVVTG SFLMEPANDS
STLPCLPLPA LFNEEPASGQ MCLEKTDQMP MPSSSSSLSC LNLPEGPIQF VSTISTLPQG
LWQISGAGTG VSSIFIYHGE VPQASQVPPP SGLTVHGLPT SPDRPGSTSP FAPSATDLPS
MPEPALTSRA NMTEHKTSPT QSQAAGEVSN KLPKWPEPVE QFYRSLQDTY RAEPAGPDGI
LVEVDLVRAR LERSSSKSLE RELATPDWAE RQLAQGGLAE LLLAAKEHRR PRETRVIAVL
GKAGQGKSCW AGAVSRAWAC GRLPQYDFVF SVPCHCLNRP GSAYRLQDLL FSLGPQPLVA
ADEVFSHILK RPDRVLLILD AFEELEAQDG FLHSTCGPAP AEPCSLRGLL AGLFQKTLLR
GCTLLLTARP RGRLGQSLSK ADTLFELSGF STEQAQAYVM RYFESSGMTE HQDRALTLLQ
DRPFLLSHSH SPTLCRAVCQ LSEALLELGD DAKLPSTLTG LYVGLLGRAA LNSPPGALAE
LAKLAWELGR RHQSTLQEDQ FPSADVRNWA MAKGLVKHPP GAAESELAFP SFLLQCFLGA
LWLALNGDIK DKELPQYLGV PRFLAGLIFQ PXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX GALVGPSATA LATEAEGACE VLKRLQPGTL RARQLLELLH CAHEAEEAGI
WQHVVQELPA CLSFLGTRLT PPDAHVLGKA LEAAGQDFSL DLRSTGICPS GLGSLVGLSC
VTGFRAALSD TVALWESLRQ HGETKLLQAA EEKFTIEPFK VKSLKDVEDL GKLVQTQRTR
SSSEDTAGEL PAVRDLKKLE FALGPISGPQ AFPKLVRILT AFSSLQHLDL DALSENKIGD
EGVSQLSATF PQLKSLETLN LSQNSITDLG AYKLAEALPS LAASLLRLSL YNNCICDVGA
ESLARVLPDM VSLRVMDVQY NKFTAAGAQQ LAASLRRCPH VETLAMWTPT IPFSVQEHLQ
QQDSRISLR
//
