ID G1RID6_NOMLE Unreviewed; 393 AA.
AC G1RID6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Short chain dehydrogenase/reductase family 42E, member 1 {ECO:0000313|Ensembl:ENSNLEP00000012992.1};
GN Name=SDR42E1 {ECO:0000313|Ensembl:ENSNLEP00000012992.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000012992.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000012992.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000012992.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
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DR EMBL; ADFV01071326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003272523.1; XM_003272475.2.
DR RefSeq; XP_003272524.1; XM_003272476.2.
DR AlphaFoldDB; G1RID6; -.
DR STRING; 61853.ENSNLEP00000012992; -.
DR Ensembl; ENSNLET00000013629.2; ENSNLEP00000012992.1; ENSNLEG00000010695.2.
DR GeneID; 100588195; -.
DR KEGG; nle:100588195; -.
DR CTD; 93517; -.
DR eggNOG; KOG1430; Eukaryota.
DR GeneTree; ENSGT00940000158070; -.
DR HOGENOM; CLU_007383_6_8_1; -.
DR InParanoid; G1RID6; -.
DR OMA; IGAYKRS; -.
DR OrthoDB; 5487986at2759; -.
DR TreeFam; TF313574; -.
DR Proteomes; UP000001073; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR CDD; cd09812; 3b-HSD_like_1_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|RuleBase:RU004475};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|RuleBase:RU004475};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|RuleBase:RU004475};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004475}.
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004475"
FT TRANSMEM 367..385
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004475"
FT DOMAIN 12..284
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 393 AA; 44276 MW; 920B1F1D893B9EFB CRC64;
MDPQRPQKET VLITGGSGYF GFRLGCALNQ KGVHVILFDI SSPAQTIPEG IKFIRGDIRH
LSDVDKAFQD ADVTCVFHIA SYGMSGREQL NRNLIEEVNI RGTDNILQAC QRRRVPRLVY
TSTFNVIFGG QVIRNGDESL PYLPLHLHPD HYSRTKSIAE QKVLEANGTP LDRGDGVLRT
CALRPAGIYG PGEQRHLPRI VSYIEKGLFK FVYGDPRSLV EFVHVDNLVQ AHILASEALR
ADKGHIASGQ PYFISDGRPV NNFEFFRPLV EGLGYTFPST RLPLTLVYCF AFLTEMVHFI
LGRLYNFQPF LTRTEVYKTG VTHYFSLEKA KKELGYKAQP FDLQEAVEWF KAHGHGRSSG
SSDLECFVWD GLLVFLLIIA VLMWLPPSVI LSL
//
