ID G1RIF5_NOMLE Unreviewed; 998 AA.
AC G1RIF5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=NLR family pyrin domain containing 4 {ECO:0000313|Ensembl:ENSNLEP00000013011.2};
GN Name=NLRP4 {ECO:0000313|Ensembl:ENSNLEP00000013011.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000013011.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000013011.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000013011.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR EMBL; ADFV01100265; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01100266; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01100267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01100268; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01100269; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01100270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003277256.1; XM_003277208.1.
DR AlphaFoldDB; G1RIF5; -.
DR STRING; 61853.ENSNLEP00000013011; -.
DR Ensembl; ENSNLET00000013648.2; ENSNLEP00000013011.2; ENSNLEG00000010674.2.
DR GeneID; 100581326; -.
DR KEGG; nle:100581326; -.
DR CTD; 147945; -.
DR eggNOG; ENOG502QQ5H; Eukaryota.
DR GeneTree; ENSGT00940000162284; -.
DR HOGENOM; CLU_002274_2_1_1; -.
DR InParanoid; G1RIF5; -.
DR OMA; EEQQAWD; -.
DR OrthoDB; 55870at2759; -.
DR Proteomes; UP000001073; Chromosome 10.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0045824; P:negative regulation of innate immune response; IEA:Ensembl.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF6; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 4; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM00368; LRR_RI; 9.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 1..94
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 149..281
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 998 AA; 113571 MW; 3A05BBE0D17DAC25 CRC64;
MAASFFSDFG LMWYLEELKK EEFRKFKEHL KQMTLHLELK QIPWTEVKKA SREELANLLI
KHYEEQQAWN ITLRIFQKLD RKDLCMKVMR ERTGYTKAYQ AHAKQKFSHL WSSKSVTEIH
LYFEEEVKQE ECDHLDRLFA PKETGKQPRT VIIQGPQGIG KTTFLMKLMM AWSDNKIFRD
RFLYTFYFCC RELRELPAMS LADLISREWP DPAAPITEIV AQPERLLFII DSFEELKGGL
NEPDSDLCGD LMEKQPVQVL LSSLLRKKML PDASLLIAVK PVCPKELRDQ VTISEIYQPR
GFNESDRLVY FCCFFKDPKR AMEAFNLVRE SEQLFSICQI PLLCWILCTS LKQEMQKGKD
LALTCQSTTS VYSSFVFNLF TPEGAEGPTP QSQRQLKALC SLAAEGMWTD AFEFREDDLR
RNGVVDADIP ALLGTKILLK YGERESSYVF LHVCVQEFCA ALFYLLKGHF DHPHPAVRCV
QELLVANFKK ARRAHWIFLG CFLTGLLNKK EQEKLDAFFG FQLSQEIKQQ FHQCLKSLGE
CGDPQGQVDS LAIFYCLFEM QDPAFVKQAV NLLQEANFHI IDNADLVVSA YCLKYCSSLR
KLCFSVQNVF ETEDEHSSTS DYSLVCWHHI CSVLTTSGHL RELQVEDSTL SESTFVTWCN
QLRHPSCRLQ KLGINNVSFS GQSAQLFEVL FYQPDLKYLS LTLTKLSRDD VRSLCDALNY
PAGNVKELAL VNCRLSPIDC EVLAGLLTNN KKLAYLNVSC NQLDAGLPLL CAALCSPDAV
LVYLMLAFCH LSEQCCEYIS EMLLRNKSVR YLDLSANVLK DEGLKTLCEA LKRPDCCLDC
CLDSLCLVKC FITADGCEDL ASALISNQNL KILQIGCNEI GDVGVQLLCR ALTHPDCRLE
ILGLEECGLT SACCKDLASV LTSSKMLQQL NLTLNALDHT GVVVLCEALR HPACALQVLG
LRKTDFDEET QALLTAEEER NPDLTITDEF DTITRVEI
//
