ID G1RJ41_NOMLE Unreviewed; 614 AA.
AC G1RJ41;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Wntless-like transmembrane domain-containing protein {ECO:0000259|Pfam:PF06664};
GN Name=TMEM181 {ECO:0000313|Ensembl:ENSNLEP00000013248.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000013248.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000013248.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000013248.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01067925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01067926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01067927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01067928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01067929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01067930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01067931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01067932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01067933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01067934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1RJ41; -.
DR Ensembl; ENSNLET00000013901.2; ENSNLEP00000013248.2; ENSNLEG00000010915.2.
DR eggNOG; ENOG502QPXU; Eukaryota.
DR GeneTree; ENSGT00390000007183; -.
DR HOGENOM; CLU_040299_0_0_1; -.
DR InParanoid; G1RJ41; -.
DR OMA; QQLWVIA; -.
DR TreeFam; TF324083; -.
DR Proteomes; UP000001073; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015643; F:toxic substance binding; IEA:InterPro.
DR InterPro; IPR040416; TMEM181.
DR InterPro; IPR047843; WLS-like_TM.
DR PANTHER; PTHR31918; TRANSMEMBRANE PROTEIN 181; 1.
DR PANTHER; PTHR31918:SF1; TRANSMEMBRANE PROTEIN 181; 1.
DR Pfam; PF06664; MIG-14_Wnt-bd; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 151..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 349..368
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 532..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 262..562
FT /note="Wntless-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF06664"
FT REGION 1..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..61
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 614 AA; 69762 MW; 1321155074C29406 CRC64;
DGAAPSPTQT PSRGGRILTR PVSGSSGARG GALSAPGPLP ARPLPTSPAP APPPPRSRPA
RRQPDPQCWE ERGGAGGDTK GGAAGPGPGR LRGMDAEYPA FEPPLCSELK HLCRRLREAY
RELKEDLTPF KDDRYYRLAP MRLYTLSKRH FVLVFVVFFI CFGLTVFVGI RGPKVIQTSA
ANFSLNNSKK LKPIQILSNP LSTYNQQLWL TCIVELDQSK ETSIKTSFPM TVKVDGVAQD
GTTMYIHNKV HNRTRTLTCA GKCAEIIVAH LGYLNYTQYT VIVGFEHLKL PIKGMNFTWK
TYNPAFSRLE IWFRFFFVVL TFIVTCLFAH SLRKFSMRDW GIEQKWMSVL LPLLLLYNDP
FFPLSFLVNS WLPGMLDDLF QSMFLCALLL FWLCVYHGIR VQGERKCLTF YLPKFFIVGL
LWLASVTLGI WQTVNELHDP MYQYRVDTGN FQGMKVFFMV VSAVYVLYLL FLIVRACSEL
RHMPYVDLRL KFLTALTFVV LVISIAILYL RFGAQVLQDN FVAELSTHYQ NYILLTGAEF
LSFYGLLNFY LYTLAFVYSP SKNALYESQL KDNPAFSMLN DSDDDVIYGS DYEEMPLQNG
QAIRAKYKEE SDSD
//
