ID G1RJM8_NOMLE Unreviewed; 110 AA.
AC G1RJM8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 3.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Mitochondrial inner membrane protease subunit {ECO:0000256|RuleBase:RU362041};
DE EC=3.4.21.- {ECO:0000256|RuleBase:RU362041};
GN Name=IMMP2L {ECO:0000313|Ensembl:ENSNLEP00000013435.3};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000013435.3, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000013435.3, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000013435.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the removal of transit peptides required for the
CC targeting of proteins from the mitochondrial matrix, across the inner
CC membrane, into the inter-membrane space. Known to process the nuclear
CC encoded protein DIABLO. {ECO:0000256|ARBA:ARBA00025546}.
CC -!- SUBUNIT: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
CC {ECO:0000256|ARBA:ARBA00011805}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004434}.
CC -!- SIMILARITY: Belongs to the peptidase S26 family. IMP2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007066}.
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DR EMBL; ADFV01195384; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195385; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195386; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195387; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195388; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195391; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01195393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1RJM8; -.
DR Ensembl; ENSNLET00000014102.3; ENSNLEP00000013435.3; ENSNLEG00000011071.3.
DR eggNOG; KOG1568; Eukaryota.
DR GeneTree; ENSGT00550000075044; -.
DR HOGENOM; CLU_173427_0_0_1; -.
DR OrthoDB; 47974at2759; -.
DR Proteomes; UP000001073; Chromosome 13.
DR GO; GO:0042720; C:mitochondrial inner membrane peptidase complex; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006627; P:protein processing involved in protein targeting to mitochondrion; IEA:InterPro.
DR GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR CDD; cd06530; S26_SPase_I; 1.
DR Gene3D; 2.10.109.10; Umud Fragment, subunit A; 1.
DR InterPro; IPR037730; IMP2.
DR InterPro; IPR036286; LexA/Signal_pep-like_sf.
DR InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR InterPro; IPR019533; Peptidase_S26.
DR NCBIfam; TIGR02227; sigpep_I_bact; 1.
DR PANTHER; PTHR46041; MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2; 1.
DR PANTHER; PTHR46041:SF2; MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2; 1.
DR Pfam; PF10502; Peptidase_S26; 1.
DR SUPFAM; SSF51306; LexA/Signal peptidase; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU362041};
KW Membrane {ECO:0000256|ARBA:ARBA00022792, ECO:0000256|RuleBase:RU362041};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW ECO:0000256|RuleBase:RU362041};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792,
KW ECO:0000256|RuleBase:RU362041}; Protease {ECO:0000256|RuleBase:RU362041};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 15..102
FT /note="Peptidase S26"
FT /evidence="ECO:0000259|Pfam:PF10502"
FT ACT_SITE 43
FT /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
FT ACT_SITE 91
FT /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
SQ SEQUENCE 110 AA; 12259 MW; A8A5A2CB8B120D4F CRC64;
MAQSQGWVKR YIKAFCKGFF VAVPVAVTFL DRVACVARVE GASMQPSLNP GGSQSSDVVL
LNHWKVRNFE VHRGDIVSLV SPKNPEQKII KRVIALEGDI VRDGRKLKRI
//
