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Database: UniProt
Entry: G1RK08_NOMLE
LinkDB: G1RK08_NOMLE
Original site: G1RK08_NOMLE 
ID   G1RK08_NOMLE            Unreviewed;       671 AA.
AC   G1RK08;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 2.
DT   20-JUN-2018, entry version 44.
DE   SubName: Full=SH2B adaptor protein 1 {ECO:0000313|Ensembl:ENSNLEP00000013565};
GN   Name=SH2B1 {ECO:0000313|Ensembl:ENSNLEP00000013565};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000013565, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000013565}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000013565}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; ADFV01196797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01196798; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01196799; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_012360782.1; XM_012505328.1.
DR   STRING; 61853.ENSNLEP00000013565; -.
DR   Ensembl; ENSNLET00000014238; ENSNLEP00000013565; ENSNLEG00000011102.
DR   GeneID; 100587926; -.
DR   CTD; 25970; -.
DR   eggNOG; ENOG410IMWK; Eukaryota.
DR   eggNOG; ENOG41102PH; LUCA.
DR   GeneTree; ENSGT00530000063355; -.
DR   InParanoid; G1RK08; -.
DR   OMA; GDRWTHR; -.
DR   OrthoDB; EOG091G04RI; -.
DR   Proteomes; UP000001073; Chromosome 2.
DR   GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd10346; SH2_SH2B_family; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR015012; Phe_ZIP.
DR   InterPro; IPR036290; Phe_ZIP_sf.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR030523; SH2B.
DR   InterPro; IPR030521; SH2B1.
DR   InterPro; IPR035057; SH2B1_SH2.
DR   PANTHER; PTHR10872; PTHR10872; 1.
DR   PANTHER; PTHR10872:SF3; PTHR10872:SF3; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF08916; Phe_ZIP; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF109805; SSF109805; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT   DOMAIN      527    625       SH2. {ECO:0000259|PROSITE:PS50001}.
SQ   SEQUENCE   671 AA;  70795 MW;  EEC08256AFB50F0F CRC64;
     MNGAPSPEDG ATPSSPPLPP PPPPSWREFC ESHARAAALD FARRFRLYLA SHPQYAGPGA
     EAAFSRRFAE LFLQHFEAEV ARASGSLSPP ILAPLSPGAE ISPHDLSLES CRVGGPLAVL
     GPSRSSEDLA GPLPSSVSSS STTSSKPKLK KRFSLRSVGR SVRGSVRGIL QWRGTVDPAS
     SAGPLETSSG PPVLGGNSNS NSSGGAGTVG RGLVSDGTSP GERWTHRFER LRLSRGGGTL
     KDGAGMVQRE ELLSFMGAEE AAPDPAGVGR GGGVAGPPSG GGGQPQWQKC RLLLRSEGEG
     GGGSRLEFFV PPKASRPRLS IPCSSITDVR TTTALEMPDR ENTFVVKVEG PSEYILETVD
     AQHVKAWVSD IQECLSPGPC PATSPRPMTL PLAPGTSFLT RENTDSLELS CLNHSESLPS
     QDLLLGPSES NDRLSQGAYG GLSDRPSASI SPSSASIAAS HFDSMELLPP ELPPRIPIEE
     GPPAGTVHPL SAPYPPLDTP ETATGSFLFQ GEPESGEGDQ PLSGYPWFHG MLSRLKAAQL
     VLTGGTGSHG VFLVRQSETR RGEYVLTFNF QGKAKHLRLS LNEEGQCRVQ HLWFQSIFDM
     LEHFRVHPIP LESGGSSDVV LVSYVPSSQR QQGREQAGSH AGVCEGDGCH PDASCTLMPF
     GASDCVTEHL P
//
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