ID G1RMG3_NOMLE Unreviewed; 448 AA.
AC G1RMG3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Procollagen C-endopeptidase enhancer {ECO:0000313|Ensembl:ENSNLEP00000014427.1};
GN Name=PCOLCE {ECO:0000313|Ensembl:ENSNLEP00000014427.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000014427.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000014427.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000014427.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR EMBL; ADFV01105354; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01105355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1RMG3; -.
DR STRING; 61853.ENSNLEP00000014427; -.
DR Ensembl; ENSNLET00000015144.2; ENSNLEP00000014427.1; ENSNLEG00000011817.2.
DR eggNOG; ENOG502QTZ9; Eukaryota.
DR GeneTree; ENSGT00940000159264; -.
DR HOGENOM; CLU_034096_0_0_1; -.
DR InParanoid; G1RMG3; -.
DR OMA; WDEHQFC; -.
DR TreeFam; TF316506; -.
DR Proteomes; UP000001073; Chromosome 17.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005518; F:collagen binding; IEA:Ensembl.
DR GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR GO; GO:0016504; F:peptidase activator activity; IEA:Ensembl.
DR CDD; cd00041; CUB; 2.
DR CDD; cd03576; NTR_PCOLCE; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR035814; NTR_PCOLCE.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR PANTHER; PTHR24251:SF24; PROCOLLAGEN C-ENDOPEPTIDASE ENHANCER 1; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00042; CUB; 2.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00059}; Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..448
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003420127"
FT DOMAIN 37..149
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 159..273
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 318..436
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT REGION 271..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 429..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 159..186
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 448 AA; 48013 MW; D76FFAE1648AD3DA CRC64;
MLPAATASLL GPLLTAWALL PFAQGQTPNY TRPVFLCGGD VKGESGYVAS EGFPNLYPPN
KECIWTITVP EGQTVSLSFR VFDLELHPAC RYDALEVFAG SGTSGQRLGR FCGTFRPAPL
VAPGNQVTLR MTADEGTGGR GFLLWYSGRA TSGTEHQFCG GRLEKAQGTL TTPNWPESDY
PPGISCSWHI IAPPDQVIAL TFEKFDLEPD TYCRYDSVSV FNGAVSDDSR RLGKFCGDAV
PGSISSEGNE LLVQFVSDLS VTADGFSASY KTLPRGTAKE GQGPSPKPGT EPKVKLPPKS
QPLEKKEETP SAPDAPTCPK QCRRTGTLQS NFCASSLVVT ATVKSMVREP GEGLTVTVSL
IGAYKTGGLD LPSPPTGASL KFYVPCKQCP PMKKGVSYLL MGQVENRGPV LPPESFVVLH
RPNQDQILTN LSKRKCPSQP VRAAESQD
//
