ID G1RMQ6_NOMLE Unreviewed; 2031 AA.
AC G1RMQ6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=Myosin X {ECO:0000313|Ensembl:ENSNLEP00000014520.2};
GN Name=MYO10 {ECO:0000313|Ensembl:ENSNLEP00000014520.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000014520.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000014520.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000014520.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01015095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01015096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01015097; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01015098; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01015099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01015100; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01015101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01015102; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01015103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01015104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 61853.ENSNLEP00000014520; -.
DR Ensembl; ENSNLET00000015242.2; ENSNLEP00000014520.2; ENSNLEG00000011899.3.
DR eggNOG; KOG4229; Eukaryota.
DR GeneTree; ENSGT00940000155469; -.
DR HOGENOM; CLU_001626_1_0_1; -.
DR InParanoid; G1RMQ6; -.
DR OMA; HYDVRGI; -.
DR TreeFam; TF316834; -.
DR Proteomes; UP000001073; Chromosome 6.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0030175; C:filopodium; IEA:Ensembl.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030507; F:spectrin binding; IEA:Ensembl.
DR GO; GO:0022409; P:positive regulation of cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR GO; GO:0051489; P:regulation of filopodium assembly; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13202; FERM_C_MyoX; 1.
DR CDD; cd17206; FERM_F1_Myosin-X; 1.
DR CDD; cd14873; MYSc_Myo10; 1.
DR CDD; cd13296; PH2_MyoX; 1.
DR CDD; cd13297; PH3_MyoX-like; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR031971; MYO10_CC.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041797; MyoX_FERM_C.
DR InterPro; IPR040640; MyoX_N_SH3.
DR InterPro; IPR036124; MYSc_Myo10.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR PANTHER; PTHR46049; AGAP003327-PA; 1.
DR PANTHER; PTHR46049:SF2; UNCONVENTIONAL MYOSIN-X; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 3.
DR Pfam; PF16735; MYO10_CC; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF18597; SH3_19; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 1.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 4.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50200; RA; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 65..734
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1207..1305
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1387..1492
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1492..1668
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1673..2017
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1677..1726
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 614..636
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 814..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 842..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 959..1085
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1026
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1073
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 159..166
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2031 AA; 234160 MW; E1FA978F60117526 CRC64;
IDNFNWETGG TRVWLRENGQ HFPSTVNSCA EGIVVFRTDY GQVFTYKQST ITHQKVTAMH
PMNEEGVDDM ASLTELHGGS IMYNLFQRYK RNQIYTYIGS ILASVNPYQP IAGLYEPATM
EQYSRRHLGE LPPHIFAIAN ECYRCLWKRH DNQCILISGE SGAGKTESTK LILKFLSVIS
QQSLELSLKE KTSCVERAIL ESSPIMEAFG NAKTVYNNNS SRFGKFVQLN ICQKGNIQGG
RINRVVRQNP GERNYHIFYA LLAGLEHEER EEFYLSTPEN YHYLNQSGCV EDKTISDQES
FREVTTAMDV MQFSKEEVRE VSRLLAGILH LGNIEFITAG GAQVPFKTAL GRSAELLGLD
PTQLTDALTQ RSMFLRGEEI LTPLNVQQAV DSRDSLAMAL YACCFEWVIK KINSRIKGNE
DFKSIGILDI FGFENFEVNH FEQFNINYAN EKLQEYFNKH IFSLEQLEYS REGLVWEDID
WIDNGECLDL IEKKLGLLAL INEESHFPQA TDSTLLEKLH SQHANNHFYV KPRVAVNNFG
VKHYAGEVQY DVRGILEKNR DTFRDDLLNL LRESRFDFIY DLFEHVSSRN NQDTLKCGSK
HRRPTVSSQF KDSLHSLMAT LSSSNPFFVR CIKPNMQKMP DQFDQAVVLN QLRYSGMLET
VRIRKAGYAV RRPFQDFYKR YKVLMRNLAL PEDVRGKCTS LLQLYDASNS EWQLGKTKVF
LRESLEQKLE KRREEEVTHA AMVIRAHVLG FLARKQYRKV LYCVVIIQKN YRAFLLRRRF
LHLKKAAIVF QKQLRGQIAR RVYRQLLAEK REQEEKKKQE EEEKKKREEE ERERERERRE
AELRAQQEEE TRKQQELEAL QKSQKEAELT RELEKQKENK QVEEILRLEK EIEDLQRMKE
QQELSLTEAS LQKLQERRDQ ELRRLEEEAC RAAQEFLESL NFDEIDECVR NIERSLSVGS
EFSSELAESA CEEKPNFNFS QPYPEEEVDE GFEADDDAFK DSPNPSEHGH SDQRTSGIRT
SDDSSEEDPY MNDTVVPTSP SADSTVLLAP SVQDSGSLHN SSSGESTYCM PQNAGDLPSP
DGDYDYDQDD YEDGAITSGS SVTFSNSYGS QWSPDYRCSV GTYNSSGAYR FSSEGAQSSF
EDSEEDFDSR FDTDDELSYR RDSVYSCVTL PYFHSFLYMK GGLMNSWKRR WCVLKDETFL
WFRSKQEALK QGWLHKKGGG SSTLSRRNWK KRWFVLRQSK LMYFENDSEE KLKGTVEVRT
AKEIIDNTTK ENGIDIIMVD RTFHLIAESP EDASQWFSVL SQVHASTDQE IQEMHDEQAN
PQNAVGTLDV GLIDSVCASD SPDRPNSFVI ITANRVLHCN ADTPEEMHHW ITLLQRSKGD
TRVEGQEFIV RGWLHKEVKN SPKMSSLKLK KRWFVLTHNS LDYYKSSEKN ALKLGTLVLN
SLCSVVPPDE KIFKETGYWN VTVYGRKHCY RLYTKLLNEA TRWSSAIQNV TDTKAPIDTP
TQQLIQDIKE NCLNSDVVEQ IYKRNPILRY THHPLHSPLL PLPYGDINLN STESMSDPIP
IIQGILQTGH DLRPLRDELY CQLIKQTNKV PHPGSVGNLY SWQILTCLSC TFLPSRGILK
YLKFHLKRIR EQFPGTEMEK YALFTYESLK KTKCREFVPS RDEIEALIHR QEMTSTVYCH
GGGSCKITIN SHTTAGEVVE KLIRGLAMED SRNMFALFEY NGHVDKAIES RTVVADVLAK
FEKLAATSEV GDLPWKFYFK LYCFLDTDNV PKDSVEFAFM FEQAHEAVIH GHHPAPEENL
QVLAALRLQY LQGDYTLHAA IPPLEEVYSL QRLKARISQS TKTFTPCERL EKRRTSFLEG
TLRRSFRTGS VVRQKVEEEQ MLDMWIKEEV SSARASIIDK WKKFQGMNQE QAMAKYMALI
KEWPGYGSTL FDVECKEGGF PQELWLGVSA DAVSVYKRGE GRPLEVFQYE HILSFGAPLA
NTYKIVVDER ELLFETSEVV DVAKLMKAYI SMIVKKRYST TRSASSQGSS R
//
