ID G1RN19_NOMLE Unreviewed; 1186 AA.
AC G1RN19;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Partner and localizer of BRCA2 {ECO:0000313|Ensembl:ENSNLEP00000014633.1};
GN Name=PALB2 {ECO:0000313|Ensembl:ENSNLEP00000014633.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000014633.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000014633.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000014633.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01197201; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197202; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197203; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197208; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003261721.1; XM_003261673.2.
DR AlphaFoldDB; G1RN19; -.
DR STRING; 61853.ENSNLEP00000014633; -.
DR Ensembl; ENSNLET00000015364.2; ENSNLEP00000014633.1; ENSNLEG00000012023.2.
DR GeneID; 100593417; -.
DR KEGG; nle:100593417; -.
DR CTD; 79728; -.
DR eggNOG; ENOG502QRAP; Eukaryota.
DR GeneTree; ENSGT00390000014423; -.
DR HOGENOM; CLU_008217_0_0_1; -.
DR InParanoid; G1RN19; -.
DR OMA; GHCQKED; -.
DR OrthoDB; 5404130at2759; -.
DR TreeFam; TF351544; -.
DR Proteomes; UP000001073; Chromosome 2.
DR GO; GO:1990391; C:DNA repair complex; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0048568; P:embryonic organ development; IEA:Ensembl.
DR GO; GO:0001833; P:inner cell mass cell proliferation; IEA:Ensembl.
DR GO; GO:0007498; P:mesoderm development; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0036342; P:post-anal tail morphogenesis; IEA:Ensembl.
DR GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR042417; PALB2.
DR InterPro; IPR031920; PALB2_WD40.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR14662; PARTNER AND LOCALIZER OF BRCA2; 1.
DR PANTHER; PTHR14662:SF2; PARTNER AND LOCALIZER OF BRCA2; 1.
DR Pfam; PF16756; PALB2_WD40; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 840..1184
FT /note="Partner and localiser of BRCA2 WD40"
FT /evidence="ECO:0000259|Pfam:PF16756"
FT REGION 95..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 14..41
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 124..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 774..799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1186 AA; 131366 MW; C0507A492DC9577F CRC64;
MEEPPGKPLS CEEKEKLKEK LAFLKREYSK TLARLQRAQR AEKIKHSIKK TVEEQDCLSQ
QELSPQLNHS EPKNKICVYD KLHIKTHLDE ETGEKTSITL DVGPESFNLG DGPGGLPIQG
TDDTQEHFPH RVSDPDGEQK QKLPSRRKKQ QKRTFISQER DCVFGTDSLR LSGKRLKEQE
EISSKNPTRS PVTEIRTHLL SLKSELPDSP EPVTEINEDS VLIPPTAQPE KGVDTFLRRP
NFTRATTVPL QTLSDSGSSQ HLEHIPLKGS SELTTHGLKN IRFTSPVSLE AQGKKMTVST
DNRLVSKAIS KSGQLPTSSN LEANISCSLN ELTHNNLPAN ENQNLKEQNQ TEKSLKSPSD
ALEGRNENLQ ENEILSQPKS LSLEATSPLS AEKHSCTMLE GLLFPAEYYV RTTRSMSNCQ
RKVALEAVIH SHLDVKKKGF KNKNKDASKN LNLSNEETDQ SEIRMSGTCT GQPSSRTSQK
LLSLTKVSSP AGPTEDNDLS RKAVAQVPGR RYRGKRKSAC TPASDHCEPL LPTSSPSVVN
RSKEEVTLHK YQHEKLLIRV KGKKSRHQKE DSLSWSNSAY LSLDDDAFTA PFHKDGMLSL
KQLLSFLSIT DFQLPDEDFG PLKLEKLKSC SEKPVEPFES KMFGEGHLKE GTCIFPEELS
PKRMDTEMED LEEDLIVLPG KSHPKRPNPQ SHSTKTGLSS SILLYTPLNT VAPEDNDRPT
ADVCSPAFPI LGTTPAFGPQ GSYEKASTEV TGRTCCTPQL AHLKDSVCLA SDSKQFDSSS
SPAKPHTTLQ VSGRQGQPTC DCDSVPPGTP PPIESFTFKE NQLCRNTCQE LHKHSVEQTE
TAELPASDSI NRGNLQLVSK LKNPSGSCSV DVSAMFWERA GCKEPCIITA CEDVVSLWKA
LDAWQWEKLY TWHFTEVPVL QIVPVPDVYN LVCVALGNLE IREIRALLCS SDDESEKQVL
LKSGNIKAVL GLTKRRLVSS SGTLSDQQVE VMTFAEDGGG KENQFLMPPE ETILTFAEVQ
GMQEALLGTT IMNNIVIWNL KTGQLLKKMH IDDSYQASVC HKAYSEMGLL FIVLSHPCAK
ESELLRSPVF QLIVINPKTT LSVGVMLYCL PPGQAGRFLE GDVKDHCAAA ILTSGTIAIW
DLLLGQCTAL LPPISDQHWS FVKWSGTDCH LLAGQKDGNI FVYHYS
//
