ID G1RPA4_NOMLE Unreviewed; 474 AA.
AC G1RPA4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Sorting nexin-1 {ECO:0000256|ARBA:ARBA00020434};
GN Name=SNX1 {ECO:0000313|Ensembl:ENSNLEP00000015068.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000015068.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000015068.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000015068.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004469}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00004546}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004546}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004546}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; ADFV01035618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01035619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01035620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01035621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01035622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01035623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01035624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01035625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01035626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01035627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1RPA4; -.
DR Ensembl; ENSNLET00000015823.3; ENSNLEP00000015068.2; ENSNLEG00000012400.3.
DR eggNOG; KOG2273; Eukaryota.
DR GeneTree; ENSGT00940000155889; -.
DR HOGENOM; CLU_022783_2_0_1; -.
DR Proteomes; UP000001073; Chromosome 6.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd07665; BAR_SNX1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR028660; SNX1_BAR.
DR InterPro; IPR005329; Sorting_nexin_N.
DR InterPro; IPR015404; Vps5_C.
DR PANTHER; PTHR10555; SORTING NEXIN; 1.
DR PANTHER; PTHR10555:SF129; SORTING NEXIN-1; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF03700; Sorting_nexin; 1.
DR Pfam; PF09325; Vps5; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 1..224
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 474 AA; 53593 MW; 4BB53F8B1E903021 CRC64;
MASGGGGCSA SARLPPPFPG LEPESEGAAG GSEPEAGDSD TEGEDIFTGA AVVSKHQSPK
RTTSLLPINN GSKENGIHEE QDQEPQDLFA DATVELSLDS TQNNQKKVPA RTLISLPPQE
ATNSSKPQPT YEELEEEEQE DQFDLTVGIT DPEKIGDGMN AYVAYKVTTQ MTKVKVGKED
SSSAEFLEKR RAALERYLQR IVNHPTMLQD PDVREFLEKE ELPRAVGTQT LSGAGLLKMF
NKATDAVSKM TIKMNESDIW FEEKLQEVEC EEQRLRKLHA VVETLVNHRK ELALNTAQFA
KSLAMLGSSE DNTALSRALS QLAEVEEKIE QLHQEQANND FFLLAELLSD YIRLLAIVRA
AFDQRMKTWQ RWQDAQATLQ KKREAEARLL WANKPDKLQQ AKDEILEWES RVTQYERDFE
RISTVVRKEV IRFEKEKSKD FKNHVIKYLE TLLYSQQQLA KYWEAFLPEA KAIS
//
