ID G1RPJ8_NOMLE Unreviewed; 500 AA.
AC G1RPJ8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Interferon regulatory factor 5 {ECO:0000313|Ensembl:ENSNLEP00000015162.1};
GN Name=IRF5 {ECO:0000313|Ensembl:ENSNLEP00000015162.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000015162.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000015162.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000015162.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01196107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003261356.1; XM_003261308.2.
DR AlphaFoldDB; G1RPJ8; -.
DR Ensembl; ENSNLET00000015919.2; ENSNLEP00000015162.1; ENSNLEG00000012454.2.
DR GeneID; 100596283; -.
DR KEGG; nle:100596283; -.
DR CTD; 3663; -.
DR eggNOG; ENOG502QSKM; Eukaryota.
DR GeneTree; ENSGT00940000159926; -.
DR HOGENOM; CLU_031544_0_0_1; -.
DR OrthoDB; 3740806at2759; -.
DR TreeFam; TF328512; -.
DR Proteomes; UP000001073; Chromosome 13.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd00103; IRF; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR019817; Interferon_reg_fac_CS.
DR InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
DR InterPro; IPR019471; Interferon_reg_factor-3.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11949; INTERFERON REGULATORY FACTOR; 1.
DR PANTHER; PTHR11949:SF10; INTERFERON REGULATORY FACTOR 5; 1.
DR Pfam; PF00605; IRF; 1.
DR Pfam; PF10401; IRF-3; 1.
DR PRINTS; PR00267; INTFRNREGFCT.
DR SMART; SM00348; IRF; 1.
DR SMART; SM01243; IRF-3; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00601; IRF_1; 1.
DR PROSITE; PS51507; IRF_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 14..122
FT /note="IRF tryptophan pentad repeat"
FT /evidence="ECO:0000259|PROSITE:PS51507"
FT REGION 120..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..211
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 500 AA; 56155 MW; 9B0FC9AFCF2F9C84 CRC64;
MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA TRHGPSQDGD
NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF RLIYDGPRDM PPQPYKIYEV
CSNGPAPTDS QPPEDYSFGA GEEEEEEEEE LQKMLPSLSL TDAVQSGPHV APYSLLKEDV
KWPPTLQPPV VLGPPAPDPS PLAPPPGNPA GFRELLPEVL EPGPLAASLP PAGEQLLPDL
LISPHMLPLT DLEIKFQYRG RPPRALTISN PHGCRLFYSQ LEATQEQVEL FGPISLEQVR
FPSPEDIPSD KQRFYTNQLL DVLDRGLILQ LQGQDLYAIR LCQCKVFWSG PCASAHDSCP
NPIQREVKTK LFSLEHFLNE LILFQKGQTN TPPPFEIFFC FGEEWPDRKP REKKLITVQV
VPVAARLLLE MFSGELSWSA DSIRLQISNP DLKDRMVEQF KELHHIWQSQ QRLQPVAQAP
PGAGLGVGQG PWPMHPAGMQ
//
