ID G1RQK0_NOMLE Unreviewed; 565 AA.
AC G1RQK0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Regulator of G protein signaling 14 {ECO:0000313|Ensembl:ENSNLEP00000015514.3};
GN Name=RGS14 {ECO:0000313|Ensembl:ENSNLEP00000015514.3};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000015514.3, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000015514.3, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000015514.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01124997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01124998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1RQK0; -.
DR STRING; 61853.ENSNLEP00000015514; -.
DR Ensembl; ENSNLET00000016302.3; ENSNLEP00000015514.3; ENSNLEG00000012773.3.
DR eggNOG; KOG3589; Eukaryota.
DR GeneTree; ENSGT00940000161364; -.
DR HOGENOM; CLU_024780_1_1_1; -.
DR InParanoid; G1RQK0; -.
DR OMA; SQGCLPR; -.
DR TreeFam; TF328814; -.
DR Proteomes; UP000001073; Chromosome 2.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0043197; C:dendritic spine; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0005819; C:spindle; IEA:Ensembl.
DR GO; GO:0001965; F:G-protein alpha-subunit binding; IEA:InterPro.
DR GO; GO:0005092; F:GDP-dissociation inhibitor activity; IEA:Ensembl.
DR GO; GO:0032794; F:GTPase activating protein binding; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR GO; GO:0007059; P:chromosome segregation; IEA:Ensembl.
DR GO; GO:0007612; P:learning; IEA:Ensembl.
DR GO; GO:0007616; P:long-term memory; IEA:Ensembl.
DR GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0045744; P:negative regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0031914; P:negative regulation of synaptic plasticity; IEA:Ensembl.
DR GO; GO:0006913; P:nucleocytoplasmic transport; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0007051; P:spindle organization; IEA:Ensembl.
DR GO; GO:0010070; P:zygote asymmetric cell division; IEA:Ensembl.
DR CDD; cd17137; RBD1_RGS14; 1.
DR CDD; cd17139; RBD2_RGS14; 1.
DR CDD; cd08743; RGS_RGS14; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR046992; RBD1_RGS14.
DR InterPro; IPR046993; RBD2_RGS14.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR046995; RGS10/12/14-like.
DR InterPro; IPR037881; RGS14_RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45945:SF2; REGULATOR OF G-PROTEIN SIGNALING 14; 1.
DR PANTHER; PTHR45945; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00455; RBD; 2.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50898; RBD; 2.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 67..178
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 296..366
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 368..438
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT REGION 19..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 445..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 565 AA; 61649 MW; 291F2D63CE81F327 CRC64;
MPGKPKHLGV PNGRMVLAVS DGELSSTTGP QGQGEGRGSS LSIHSLPSGT SSPFPTEEQP
VASWALSFER LLQDPLGLAY FTEFLKKEFS AENVTFWKAC ERFQQIPATG EARNIYQEFL
SSQALSPVNI DRQAWLGEEV LAEPRPDMFR AQQLQIFNLM KFDSYARFVK SPLYRECLLA
EAEGRPLREP GSSRLGSPDA TRKKPKLKPG KSLPLGVEEL GQLPPVEGPG GRSLRKSFRR
ELGGTANAAL RRESQGSLNS SASLDLGFLA FVSSKSESHR KSLGSTEGES ESRPGKYCCV
YLPDGTASLA LARPGLTIRD MLAGICEKRG LSLPDIKVYL VGNEQALVLD QDCTVLADQE
VRLENRITFE LELTALERVV RISAKPTKRL QEALQPILEK HGLSPLQVSL HRPGEKEPLD
LGKLVSSVAA QKLVLDTLPG VKISKARDKS PCRSQGCPPR TQDKATHPPP ASPSSLVKVP
SSATGKRQTC DIEGTWWMSW GSERLGQWGW GPFRVRGLLR KEDLVLPEFL QLPTQQPSSQ
DTPQQTESAA QPIGGSLNST TDSAL
//
