ID G1RRZ7_NOMLE Unreviewed; 1278 AA.
AC G1RRZ7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Kinase D interacting substrate 220 {ECO:0000313|Ensembl:ENSNLEP00000016019.2};
GN Name=KIDINS220 {ECO:0000313|Ensembl:ENSNLEP00000016019.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000016019.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000016019.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000016019.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01072973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01072974; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01072975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01072976; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01072977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1RRZ7; -.
DR Ensembl; ENSNLET00000016837.3; ENSNLEP00000016019.2; ENSNLEG00000013206.3.
DR eggNOG; KOG0502; Eukaryota.
DR GeneTree; ENSGT00940000156714; -.
DR HOGENOM; CLU_001438_2_0_1; -.
DR TreeFam; TF344032; -.
DR Proteomes; UP000001073; Chromosome 19.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011646; KAP_P-loop.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR24116; KINASE D-INTERACTING SUBSTRATE OF 220 KDA; 1.
DR PANTHER; PTHR24116:SF0; KINASE D-INTERACTING SUBSTRATE OF 220 KDA; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF07693; KAP_NTPase; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 10.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 8.
DR PROSITE; PS50088; ANK_REPEAT; 9.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 459..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 618..642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 648..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 37..69
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 70..102
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 103..135
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 136..168
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 169..201
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 202..234
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 235..267
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 268..300
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 334..366
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 402..914
FT /note="KAP NTPase"
FT /evidence="ECO:0000259|Pfam:PF07693"
FT REGION 1190..1227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1278 AA; 142266 MW; AA44D1AE4F8D3851 CRC64;
MSVLISQSVI NYVEEENIPA LKALLEKCKD VDERNECGQT PLMIAAEQGN LEIVKELIKN
GANCNLEDLD NWTALISASK EGHVHIVEEL LKCGVNLEHR DMGGWTALMW ACYKGRTDVV
ELLLSHAANP SVTGLYSVYP IIWAAGRGHA DIVHLLLQNG AKVNCSDKYG TTPLVWAARK
GHLECVKHLL AMGADVDQEG ANSMTALIVA VKGGYTQSVK EILKRNPNVN LTDKDGNTAL
MIASKEGHTE IVQDLLDAGT YVNIPDRSGD TVLIGAVRGG HVEIVRALLQ KYADIDIRGQ
DNKTALYWAV EKGNATMVRD ILQCNPDTEI CTKDGETPLI KATKMRNIEV VELLLDKGAK
VSAVDKVKHL CGESTVWKAV GRLTSIWRHL SPTETDGDML GYDLYSSALA DILSEPTMQP
PICVGLYAQW GSGKSFLLKK LEDEMKTFAG QQIEPLFQFS WLIVFLTLLL CGGLGLLFAF
TVHPNLGIAV SLSFLALLYI FFIVIYFGGR REGESWNWAW VLSTRLARHI GYLELLLKLM
FVNPPELPEQ TTKALPVRFL FTDYNRLSSV GGETSLAEMI ATLSDACERE FGFLATRLFR
VFKTEDTQGK KKWKKTCCLP SFVIFLFIIG CIISGITLLA IFRVDPKHLT VNAVLISIAS
IVGLAFVLNC RTWWQVLDSL LNSQRKRLHN AASKLHKLKS EGFMKVLKCE VELMARMAKT
IDSFTQNQTR LVVIIDGLDA CEQDKVLQML DTVRVLFSKG PFIAIFASDP HIIIKAINQN
LNSVLRDSNI NGHDYMRNIV HLPVFLNSRG LSNARKFLVT SATNGDVPCS DTTGIQEDAD
RRVSQNSLGE MTKLGSKTAL NRRDTYRRRQ MQRTITRQMS FDLTKLLVTE DWFSDISPQT
MRRLLNIVSV TGRLLRANQI SFNWDRLASW INLTEQWPYR TSWLILYLEE TEGIPDQMTL
KTIYERISKN IPTTKDVEPL LEIDGDIRNF EVFLSSRTPV LVARDVKVFL PCTVNLDPKL
REIIADVRAA REQISIGGLA YPPLPLHEGP PRAPSGYSQP PSVCSSTSFN GPFAGGVVSP
QPHSSYYSGM TGPQHPFYNR GSGPAPGPVV LLNSLNVDAV CEKLKQIEGL DQSMLPQYCA
TIKKANINGR VLAQCNIDEL KKEMNMNFGD WHLFRSTVLE MRNAESHVVP EDPRFLSESS
SGPAPHSEPA RRASHNELPH TELSGQTPYT LNFSFEELNT LGLDEGAPRH SNLSWQTHAD
TGQKGRNQWG YCSFAGAA
//
