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Database: UniProt
Entry: G1RTC9_NOMLE
LinkDB: G1RTC9_NOMLE
Original site: G1RTC9_NOMLE 
ID   G1RTC9_NOMLE            Unreviewed;       702 AA.
AC   G1RTC9;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   28-MAR-2018, entry version 27.
DE   SubName: Full=Nicastrin {ECO:0000313|Ensembl:ENSNLEP00000016503};
GN   Name=NCSTN {ECO:0000313|Ensembl:ENSNLEP00000016503};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000016503, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000016503}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000016503}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; ADFV01184014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01184015; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01184016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 61853.ENSNLEP00000016503; -.
DR   Ensembl; ENSNLET00000017349; ENSNLEP00000016503; ENSNLEG00000013620.
DR   eggNOG; KOG2657; Eukaryota.
DR   eggNOG; ENOG410XT6X; LUCA.
DR   GeneTree; ENSGT00390000014633; -.
DR   InParanoid; G1RTC9; -.
DR   OrthoDB; EOG091G03DV; -.
DR   TreeFam; TF317086; -.
DR   Proteomes; UP000001073; Chromosome 12.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0070765; C:gamma-secretase complex; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR   GO; GO:0004175; F:endopeptidase activity; IEA:Ensembl.
DR   GO; GO:0034205; P:amyloid-beta formation; IEA:Ensembl.
DR   GO; GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0006509; P:membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0002262; P:myeloid cell homeostasis; IEA:Ensembl.
DR   GO; GO:0043085; P:positive regulation of catalytic activity; IEA:Ensembl.
DR   GO; GO:0016485; P:protein processing; IEA:Ensembl.
DR   GO; GO:0042098; P:T cell proliferation; IEA:Ensembl.
DR   InterPro; IPR008710; Nicastrin.
DR   PANTHER; PTHR21092; PTHR21092; 1.
DR   Pfam; PF05450; Nicastrin; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     33       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        34    702       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014118812.
FT   TRANSMEM    663    683       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   702 AA;  77419 MW;  5D95C03D10BABC66 CRC64;
     MATAGGGSGA DPGSRGLLRV LSFCVLLAGL CRGNSVERKI YIPLNKTAPC VRLLNATHQI
     GCQSSISGDT GVIHVVEKEE DLQWVLTDGP NPPYMVLLES KLFTRDVMEK LKGRTSRIAG
     LAVSLTKPSP ASGFSPSVQC PNDGFGVYSN SYGPEFAHCR ETQWNSLGNG LAYEDFSFPI
     FLLEDENETK VIKQCYQDHN LSQNGSAPTF PLCAMQLFSH MHAVISTATC MRRSSIQSTF
     SINPEIVCDP LSDYNVWSML KPINTTGTLK PDDRVVVAAT RLDSRSFFWN VAPGAESAVA
     SFVTQLAAAE ALQKAPDVTT LPRNVMFVFF QGETFDYIGS SRMVYDMEKG KFPVQLENVD
     SFVELGQTSC FPSPSLPSVN LPRTPQVEDL LVTLEKSGAG VPAVILRRPN QSQPLPPSSL
     QRFLRARNIS GVVLADHSGA FHNKYYQSIY DTAENINMSY PEWLSPEEDL NFVTDTAKAL
     ADVATVLGRA LYELAGGTNF SDTVQADPQT VTRLLYGFLI KANNSWFQSI LRQDLRSYLG
     DGPLQHYIAV SSPTNTTYVV QYALANLTGT VVNLTREQCQ DPSKVPSENK DLYEYSWVQG
     PLNSNETDRL PRCVRSTARL ARALSPAFEL SQWSSTEYST WTESRWKDIR ARIFLIASKE
     LEFITLIVGF GILIFSLIVT YCINAKADVL FIAPREPGAV SY
//
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