ID G1RWJ6_NOMLE Unreviewed; 667 AA.
AC G1RWJ6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=ATP-dependent RNA helicase DDX1 {ECO:0000256|ARBA:ARBA00014916};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE AltName: Full=DEAD box protein 1 {ECO:0000256|ARBA:ARBA00032348};
GN Name=DDX1 {ECO:0000313|Ensembl:ENSNLEP00000017623.3};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000017623.3, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000017623.3, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000017623.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic granule
CC {ECO:0000256|ARBA:ARBA00004463}. Mitochondrion
CC {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX1 subfamily.
CC {ECO:0000256|ARBA:ARBA00008765}.
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DR EMBL; ADFV01073407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1RWJ6; -.
DR Ensembl; ENSNLET00000018501.3; ENSNLEP00000017623.3; ENSNLEG00000014417.3.
DR eggNOG; KOG0349; Eukaryota.
DR GeneTree; ENSGT00940000155678; -.
DR HOGENOM; CLU_016321_0_0_1; -.
DR TreeFam; TF106114; -.
DR Proteomes; UP000001073; Chromosome 19.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR CDD; cd12873; SPRY_DDX1; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR47958; ATP-DEPENDENT RNA HELICASE DBP3; 1.
DR PANTHER; PTHR47958:SF186; ATP-DEPENDENT RNA HELICASE DDX1; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 64..241
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 249..395
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 460..648
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 667 AA; 74504 MW; B4E0E059173D5479 CRC64;
MGVMPEIAQA VEEMDWLLPT DIQAESIPLI LGGGDVLMAA ETGSGKTGAF SIPVIQIVYE
TLKDQQEGKK GKTTIKTGAS VLNKWQMNPY DRGSAFAIGS DGLCCQSREV KEWHGCRATK
GLMKGKHYYE VSCHDQGLCR VGWSTMQASL DLGTDKFGFG FGGTGKKSHN KQFDNYGEEF
TMHDTIGCYL DIDKGHVKFS KNGKDLGLAF EIPPHMKNQA LFPACVLKNA ELKFNFGEEE
FKFPPKDGFV ALSKAPDGYI VKSQHSGNAQ VTQTKFLPNA PKALIVEPSR ELAEQTLNNI
KQFKKYIDNP KLRELLIIGG VAARDHLSPV LGLMLGRKSD GLLSQGYSDF INRMHNQIPQ
VTSDGKRLQV IVCSATLHSF DVKKLSEKIM HFPTWVDLKG EDSVPDTVHH VVVPVNPKTD
RLWERLGKNH IRTDDVHAKD NTRPGANSPE MWSEAIKILK GEYAVRAIKE HKMDQAIIFC
RTKIDCDNLE QYFIQQGGGP DKKGHQFSCV CLHGDRKPHE RKQNLERFKK GDVRFLICTD
VAARGIDIHG VPYVINVTLP DEKQNYVHRI GRVGRAERMG LAISLVATEK EKVWYHVCSS
RGKGCYNTRL KEDGGCTIWY NEMQLLSEIE EHLNCTISQV EPDIKVPVDE FDGKVTYGQK
RAAGGKL
//
