ID G1RWZ6_NOMLE Unreviewed; 780 AA.
AC G1RWZ6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 66.
DE RecName: Full=Solute carrier family 26 member 9 {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Anion transporter/exchanger protein 9 {ECO:0000256|RuleBase:RU362052};
GN Name=SLC26A9 {ECO:0000313|Ensembl:ENSNLEP00000017773.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000017773.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000017773.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000017773.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Ion transporter that can act both as an ion channel and anion
CC exchanger. Mainly acts as a chloride channel, which mediate uncoupled
CC chloride anion transport in an alternate-access mechanism where a
CC saturable binding site is alternately exposed to either one or the
CC other side of the membrane. Also acts as a DIDS- and
CC thiosulfate- sensitive anion exchanger the exchange of chloride for
CC bicarbonate ions across the cell membrane.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|ARBA:ARBA00008692, ECO:0000256|RuleBase:RU362052}.
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DR EMBL; ADFV01075384; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01075385; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1RWZ6; -.
DR Ensembl; ENSNLET00000018660.2; ENSNLEP00000017773.2; ENSNLEG00000014612.2.
DR eggNOG; KOG0236; Eukaryota.
DR GeneTree; ENSGT01100000263544; -.
DR TreeFam; TF313784; -.
DR Proteomes; UP000001073; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0098661; P:inorganic anion transmembrane transport; IEA:UniProtKB-UniRule.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814:SF17; SOLUTE CARRIER FAMILY 26 MEMBER 9; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 90..117
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 124..143
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 174..199
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 251..269
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 333..356
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 403..424
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 508..726
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 591..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 780 AA; 85491 MW; 062B869E6800C58C CRC64;
MSQPRPRYVV DRAAYSLTLF DDEFEKKDRT YAVGEKLRNA FRCSSAKIKA VVFGLLPVLS
WLPKYKIKDY IIPDLLGGLS GGSIQVPQGM AFALLANLPA VNGLYSSFFP LLTYFFLGGV
HQMVPGTFAV ISILVGNICL QLAPESKFQV FNNATNESYV DTAAMEAERL HVSATLACLT
AIIQMGLGFM QFGFVAIYLS ESFIRGFMTA AGLQILISVL KYIFGLTIPS YTGPGSIVFT
FIDICKNLPH TNIASLIFAL ISGAFLVLVK ELNARYMHKI RFPIPTEMIV VVVATAISGG
YKMPKKYHMQ IVGEIQRGFP TPVSPVVSQW KDMIGTAFSL AIVSYVINLA MGRTLANKHG
YDVDSNQEMI ALGCSNFFGS FFKIHVICCA LSVTLAVDGA GGNPSLCVSL VVMITMQVLG
IYLYPLPKSV LGALIAVNLK NSLKQLTDPY YLWRKSKLDC VSIGQPLGTG HVHVPLAFSC
FSLPSSSSRN GYALAQVMDT DIYVNPKTYN RAQDIQGIKI ITYCSPLYFA NSEIFRQKVI
AKTGMDPQKV LLAKQKYLKK QEKQRMRPTQ QRRSLFMKTK TVSLQELQQD FENAPPTDPN
NNQTPANGTS VSYITFSPDS SSAAQSEPPA SAEAPGEPSD TLASVPPFVT FHTLILDMSG
VSFVDLMGIK ALAKLSSTYG KIGVKVFLVN IHAQVYNDIS HGGVFEDGSL ECKHVFPSIH
DAVLFAQANA RDVTPGRNFQ GAPGDPELSL YDSEEDIPSY WDLEQEMFGS MFHAETLTAL
//