ID G1RX85_NOMLE Unreviewed; 110 AA.
AC G1RX85;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Parvalbumin {ECO:0000256|RuleBase:RU368048};
GN Name=PVALB {ECO:0000313|Ensembl:ENSNLEP00000017862.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000017862.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000017862.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000017862.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: In muscle, parvalbumin is thought to be involved in
CC relaxation after contraction. It binds two calcium ions.
CC {ECO:0000256|ARBA:ARBA00025308, ECO:0000256|RuleBase:RU368048}.
CC -!- SIMILARITY: Belongs to the parvalbumin family.
CC {ECO:0000256|ARBA:ARBA00009753, ECO:0000256|RuleBase:RU368048}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01024311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01024312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003264754.1; XM_003264706.1.
DR AlphaFoldDB; G1RX85; -.
DR STRING; 61853.ENSNLEP00000017862; -.
DR Ensembl; ENSNLET00000018754.2; ENSNLEP00000017862.1; ENSNLEG00000014683.2.
DR GeneID; 100594467; -.
DR KEGG; nle:100594467; -.
DR CTD; 5816; -.
DR eggNOG; KOG0027; Eukaryota.
DR GeneTree; ENSGT00940000159653; -.
DR HOGENOM; CLU_157356_0_0_1; -.
DR InParanoid; G1RX85; -.
DR OMA; HRKFFQM; -.
DR OrthoDB; 3531838at2759; -.
DR TreeFam; TF332342; -.
DR Proteomes; UP000001073; Chromosome 7b.
DR GO; GO:0030424; C:axon; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0098976; P:excitatory chemical synaptic transmission; IEA:Ensembl.
DR GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR GO; GO:0098977; P:inhibitory chemical synaptic transmission; IEA:Ensembl.
DR CDD; cd16254; EFh_parvalbumin_alpha; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR008080; Parvalbumin.
DR PANTHER; PTHR11653; PARVALBUMIN ALPHA; 1.
DR PANTHER; PTHR11653:SF2; PARVALBUMIN ALPHA; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR PRINTS; PR01697; PARVALBUMIN.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU368048};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU368048};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 39..74
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 78..110
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 110 AA; 12011 MW; 05734CABE64EEA15 CRC64;
MSMTDLLNAE DIKKAVGAFS ATDSFDHKKF FQMVGLKKKS ADDVKKVFHI LDKDKSGFIE
EDELGFILKG FSPDARDLSA KETKTLMAAG DKDGDGKIGV DEFSTLVAES
//
