GenomeNet

Database: UniProt
Entry: G1RX89_NOMLE
LinkDB: G1RX89_NOMLE
Original site: G1RX89_NOMLE 
ID   G1RX89_NOMLE            Unreviewed;      1525 AA.
AC   G1RX89;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   24-JAN-2024, entry version 79.
DE   RecName: Full=ABC-type glutathione-S-conjugate transporter {ECO:0000256|ARBA:ARBA00024220};
DE            EC=7.6.2.3 {ECO:0000256|ARBA:ARBA00024220};
GN   Name=ABCC2 {ECO:0000313|Ensembl:ENSNLEP00000017866.2};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000017866.2, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000017866.2, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000017866.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene
CC         C4(out) + phosphate; Xref=Rhea:RHEA:38963, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57973, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000256|ARBA:ARBA00024162};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38964;
CC         Evidence={ECO:0000256|ARBA:ARBA00024162};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ADFV01163295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01163296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 61853.ENSNLEP00000017866; -.
DR   Ensembl; ENSNLET00000018758.2; ENSNLEP00000017866.2; ENSNLEG00000014650.2.
DR   eggNOG; KOG0054; Eukaryota.
DR   GeneTree; ENSGT00940000161741; -.
DR   HOGENOM; CLU_000604_27_3_1; -.
DR   InParanoid; G1RX89; -.
DR   OMA; RRRYILW; -.
DR   TreeFam; TF105199; -.
DR   Proteomes; UP000001073; Chromosome 3.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0046581; C:intercellular canaliculus; IEA:Ensembl.
DR   GO; GO:0015431; F:ABC-type glutathione S-conjugate transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0008559; F:ABC-type xenobiotic transporter activity; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0015127; F:bilirubin transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0015721; P:bile acid and bile salt transport; IEA:Ensembl.
DR   GO; GO:0071716; P:leukotriene transport; IEA:Ensembl.
DR   GO; GO:0046618; P:xenobiotic export from cell; IEA:Ensembl.
DR   GO; GO:0006855; P:xenobiotic transmembrane transport; IEA:Ensembl.
DR   CDD; cd18595; ABC_6TM_MRP1_2_3_6_D1_like; 1.
DR   CDD; cd18603; ABC_6TM_MRP1_2_3_6_D2_like; 1.
DR   CDD; cd03250; ABCC_MRP_domain1; 1.
DR   CDD; cd03244; ABCC_MRP_domain2; 1.
DR   Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011527; ABC1_TM_dom.
DR   InterPro; IPR036640; ABC1_TM_sf.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR005292; MRP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR00957; MRP_assoc_pro; 1.
DR   PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1.
DR   PANTHER; PTHR24223:SF176; ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 2; 1.
DR   Pfam; PF00664; ABC_membrane; 2.
DR   Pfam; PF00005; ABC_tran; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS50929; ABC_TM1F; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        31..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        64..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        98..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        129..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        162..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        317..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        358..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        437..456
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        462..480
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        537..568
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        967..1000
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1021..1041
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1103..1134
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1204..1226
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          325..605
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50929"
FT   DOMAIN          637..858
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|PROSITE:PS50893"
FT   DOMAIN          977..1261
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50929"
FT   DOMAIN          1297..1514
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|PROSITE:PS50893"
FT   REGION          253..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        260..283
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1525 AA;  171835 MW;  2171417FF831740D CRC64;
     MLEKFCNSTF WNSSFLDSPE ADLPLCFEQT VLVWIPLGFL WLLAPWQLLH VYKSRTKRSS
     TTKLYLAKQV FVGFLLILAA IELALVLTED SGQATVPAVR YTNPSLYLGT WLLVLLIQYS
     RQWCVQKNSW FLSLFWILSI LCGTFQFQTL IRTLLQGDNS NLAYSCLFFI SYGFQILILI
     FSAFSENNGS SNNPSSTASF LSSITYSWYD SIILKGYKHP LTLEDVWEVD EEMKTKTLVS
     KFETHMKREL QKARRALQRR QQKSSQQNSG ARLPGLNKNQ SQSQDVLVLE DVKKKKKKSG
     TKKDAPKSWL IKALFKTFYM VLLKSFLLKL VNDIFTFVSP QLLKLLISFA SDRDTYLWIG
     YFCAILLFAA ALIQSFCLQC YFQLCFKLGV KVRTAIMASV YKKALTLSNL ARKEYTVGET
     VNLMSVDAQK LMDVTNFMHM LWSSVLQIVL SIFFLWRELG PSVLAGVGVM VLVIPINAIL
     STKSKTIQVK NMKNKDKRLK IMNEILSGIK ILKYFAWEPS FRDQVQNLRK KELKNLLAFT
     QLQCVVIFVF QLTPVLVSVV TFSVYVLVDS NNILDAQKAF TSITLFNILR FPLSMLPMMI
     SSMLQASVST KRLEKYLGGD DLDTSAIRHD CNFDKAVQFS EASFTWEHDS EATIRDVNLD
     IMPGQLVAVM GPVGSGKSSL ISAMLGEMEN VHGHITIKGT TAYVPQQSWI QNGTIKDNIL
     FGAEFNEKRY QQVLEACALL PDLEMLPGGD LAEIGEKVLR ITRDLQGLAR ATYQNLDIYL
     LDDPLSAVDA HVGKHIFNKV LGPNGLLKGK TRLLVTHSMH FLPQVDEIVV LGNGTIVEKG
     SYNALLAKKG EFAKNLKTFL RHTGPEEEAT VHDGSEEEDD DYGLISSVEE IPEDAASITM
     RRENSFRRTL SRSSRSNGRH LKSLKNSLKT RNVNSLKEDE ELVKGQKLIK KEFIETGKVK
     FSIYLEYLQA IGLFSIFFII LAFVMNSVAF VGSNLWLSAW TSDSKIFNST NYPASQRDMR
     VGVYGALGLA QGIFVFIAHF WSAFGFVHAS NILHKQLLNN ILRAPMRFFD TTPTGRIVNR
     FAGDISTVDD TLPQSLRSWI TCFLGIISTL VMICMATPVF TVIVIPLGII YVSVQMFYVS
     TSRQLRRLDS VTRSPIYSHF SETVSGLPVI RAFEHQQRFL KHNEVRIDTN QKCVFSWITS
     NRWLAIRLEL VGNLIVFFSA LMMVIYRDTL SGDTVGFVLS NALNITQTLN WLVRMTSEIE
     TNIVAVERIT EYTKVENEAP WVTDKRPPPD WPSKGKIQFN NYQVRYRPEL DLVLRGITCD
     ISSMEKIGVV GRTGAGKSSL TNCLFRILEA AGGQIIIDGV DIASIGLHDL REKLTIIPQD
     PILFSGSLRM NLDPFNNYSD EEIWKALELA HLKSFVASLQ LGLSHEVTEA GGNLSIGQRQ
     LLCLGRLCFG NPRSWVLDEA TAAFAHCTVI TIGTGLDTDG LTLVMVLDNG KIIEYGSPEE
     LLQTPGPFYF MAKEAGIENM NSTKF
//
DBGET integrated database retrieval system