ID G1S006_NOMLE Unreviewed; 1246 AA.
AC G1S006;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=RAS protein activator like 2 {ECO:0000313|Ensembl:ENSNLEP00000018834.3};
GN Name=RASAL2 {ECO:0000313|Ensembl:ENSNLEP00000018834.3};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000018834.3, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000018834.3, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000018834.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01184901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01184902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01184903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01184904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01184905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01184906; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01184907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01184908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01184909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01184910; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1S006; -.
DR Ensembl; ENSNLET00000019779.2; ENSNLEP00000018834.3; ENSNLEG00000015510.2.
DR eggNOG; KOG3508; Eukaryota.
DR GeneTree; ENSGT00940000157702; -.
DR HOGENOM; CLU_001727_1_0_1; -.
DR TreeFam; TF105303; -.
DR Proteomes; UP000001073; Chromosome 12.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF52; RAS GTPASE-ACTIVATING PROTEIN NGAP; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 34..265
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 256..374
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 434..626
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 72..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 858..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 910..1061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1223..1246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1073..1159
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 75..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..942
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..961
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1018..1060
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1246 AA; 140410 MW; FBF5D8D9A1E326C9 CRC64;
PSLNQAITSV SHTLLRPLVF PPLSSSYVKG PPTHRLSCGQ SPYTETTTWE RKYCILTDSQ
LVLLNKEKEI PVEGGQEQQT DSTKGRCLRR TVSVPSEGQF PEYPPEGATK LEVPAERSPR
RRSISGTSTS EKPNSMDTVN TSPFKVPGFF SKRLKGSIKR TKSQSKLDRN TSFRLPSLRS
TDDRSRGLPK LKESRSHESL LSPCSAVECL DLGRGEPVSV KPLHSSILGQ DFCFEVTYLS
GSKCFSCNSA SERDKWMENL RRTVQPNKDN CRRAENVLRL WIIEAKDLAP KKKYFCELCL
DDTLFARTTS KTKADNIFWG EHFEFFSLPP LHSITVHIYK DVEKKKKKDK NNYVGLVNIP
TASVTGRQFV EKWYPVSTPT PNKGKTGGPS IRIKSRFQTI TILPMEQYKE FAEFVTSNYT
MLCSVLEPVI SVRNKEELAC ALVHILQSTG RAKDFLTDLV MSEVDRCGEH DVLIFRENTI
ATKSIEEYLK LVGQQYLHDA LGEFIKALYE SDENCEVDPS KCSSSELIDH QSNLKMCCEL
AFCKIINSYC VFPRELKEVF ASWKQQCLNR GKQDISERLI SASLFLRFLC PAIMSPSLFN
LMQEYPDDRT SRTLTLIAKV IQNLANFAKF GNKEEYMAFM NDFLEHEWGG MKRFLLEISN
PDTISNTPGF DGYIDLGREL SVLHSLLWEV VSQLDKGENS FLQATVAKLG PLPRVLADIT
KSLTNPTPIQ QQLRRFTEHN SSPNVSGSLS SGLQKIFEDP TDSDLHKLKS PSQDNTDSYF
RGKTLLLVQQ ASSQSMTYSE KDERESSLPN GRSVSLMDLQ DTHAAQVEHA SVMLDVPIRL
TGSQLSITQV ASIKQLRETQ STPQSAPQVR RPLHPALNQP GGLQPLSFQN PVYHLNNPIP
AMPKASIDSS LENLSTASSR SQSNSEDFKL SGPSNSSMED FTKRSTQSED FSRRHTVPDR
HIPLALPRQN STGQAQIRKV DQGGLGARAK APPSLPHSAS LRSTGSMSVA SAALVAEPVQ
NGSRSRQQSS SSRESPVPKV RAIQRQRTQQ VQSPVDSATM SPVERTAAWV LNNGQYEEDV
EETEQNQDEA KHAEKYEQEI TKLKERLRVS SRRLEEYERR LLVQEQQMQK LLLEYKARLE
DSEERLRRQQ EEKDSQMKSI ISRLMAVEEE LKKDHAEMQA VIDAKQKIID AQEKRIVSLD
SANTRLMSAL TQVKERYSMQ VRNGISPTNP TKLSITENGE FKNSSC
//
