ID G1S037_NOMLE Unreviewed; 541 AA.
AC G1S037;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN Name=ACSS1 {ECO:0000313|Ensembl:ENSNLEP00000018865.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000018865.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000018865.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000018865.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01107841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01107842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01107843; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01107844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01107845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01107846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01107847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1S037; -.
DR Ensembl; ENSNLET00000019812.2; ENSNLEP00000018865.2; ENSNLEG00000015554.2.
DR eggNOG; KOG1175; Eukaryota.
DR GeneTree; ENSGT00940000158550; -.
DR HOGENOM; CLU_000022_3_0_1; -.
DR TreeFam; TF354241; -.
DR Proteomes; UP000001073; Chromosome 13.
DR GO; GO:0016878; F:acid-thiol ligase activity; IEA:UniProt.
DR GO; GO:0016405; F:CoA-ligase activity; IEA:UniProt.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF110; ACETYL-COENZYME A SYNTHETASE 2-LIKE, MITOCHONDRIAL; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 51..107
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 109..501
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT REGION 15..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 541 AA; 58962 MW; 0356C3368CF51C04 CRC64;
MAARTLSRGV GRLLGSLRGL SGQPARPPRR AASGPTGSAP AVAAAAQPGS YPALSAQAAR
EPAAFWGSLA RDTLVWDTPY HTVWDCDFST GKIGWFLGGQ LNVSVNCLDQ HVQKSPESVA
LIWERDEPGT EVRITYRELL ETTCRLANTL KTHGVHRGDR VAIYMPVSPL AVAAMLACAR
IGAVHTVIFA GFSAESLAGR INDAKCKVVI TFNQGLRGGR VVELKKIVDE AVKHCPTVQH
VLVAHRTDSK VHMGDLDVPL EQEMAKEDPV CAPESMGSED MLFMLYTSGS TGMPKGIVHT
QAGYLLYAAL THKLVFDHQP GDIFGCVADI GWITGHSYVV YGPLCNGATS VLFESTPVYP
DAGRYWETVE RLKINQFYGA PTAVRLLLKY GDAWVKKYDR SSLRTLGSVG EPINCEAWEW
LHRVVGDSRC TLVDTWWQTE TGGICIAPRP SEEGAEILPA MAMRPFFGII PVLMDEKGSV
VEGSNVSGAL CISQAWPGMA RTIYGDHQRF VDAYFKAYPN MLQIVGLFRE ATRNSGDLLE
H
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