ID G1S238_NOMLE Unreviewed; 1858 AA.
AC G1S238;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Dedicator of cytokinesis 5 {ECO:0000313|Ensembl:ENSNLEP00000019576.2};
GN Name=DOCK5 {ECO:0000313|Ensembl:ENSNLEP00000019576.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000019576.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000019576.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000019576.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; ADFV01074077; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01074078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01074079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01074080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01074081; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01074082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01074083; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01074084; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01074085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01074086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSNLET00000020566.2; ENSNLEP00000019576.2; ENSNLEG00000016075.2.
DR eggNOG; KOG1998; Eukaryota.
DR GeneTree; ENSGT00940000157734; -.
DR HOGENOM; CLU_000595_2_1_1; -.
DR InParanoid; G1S238; -.
DR OMA; KPFHHSG; -.
DR TreeFam; TF300423; -.
DR Proteomes; UP000001073; Chromosome 8.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0002102; C:podosome; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046849; P:bone remodeling; IEA:Ensembl.
DR GO; GO:0016477; P:cell migration; IEA:InterPro.
DR GO; GO:1904694; P:negative regulation of vascular associated smooth muscle contraction; IEA:Ensembl.
DR GO; GO:0071800; P:podosome assembly; IEA:Ensembl.
DR GO; GO:0010634; P:positive regulation of epithelial cell migration; IEA:Ensembl.
DR GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IEA:Ensembl.
DR GO; GO:1904754; P:positive regulation of vascular associated smooth muscle cell migration; IEA:Ensembl.
DR GO; GO:0016601; P:Rac protein signal transduction; IEA:Ensembl.
DR CDD; cd11708; DHR2_DOCK5; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR030717; DHR2_DOCK5.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF3; DEDICATOR OF CYTOKINESIS PROTEIN 5; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1858
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014117393"
FT DOMAIN 439..623
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1219..1630
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1667..1690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1760..1858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1667..1682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1783..1798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1832..1846
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1858 AA; 213282 MW; E28EEB05522EB12B CRC64;
ISQVTCILIS LFYFSFPAIY NYNASQDVEL SLQIGDTVHI LEMYEGKSGW PSGIFPETYI
HLKEATVEDL GQHETVIPGE LPLVQELTST LREWAVIWRK LYVNNKLTLF RQLQQMTYSL
IEWRSQILSG TLPKDELAEL KKKVTAKIDH GNRMLGLDLV VRDDNGNILD PDETSTIALF
KAHEVASKRI EEKIQEEKSI LQNFDLRGQS IFSTIHTYGL YVNFKNFVCN IGEDAELFMA
LYDPDQSTFI SENYLIRWGS NGMPKEIEKL NNLQAVFTDL SGMDLIRPRV SLVCQIVRVG
HMELKEGKKH TCGLRRPFGV AVMDITDIIH GKVDDEEKQH FIPFQQIAME TYIRQRQLIM
SPLITSHVIG ENEPLTSVLN KVIAAKEVNH KGQGLWVSLK LLPGDLTQVQ KNFSHLVDRS
TAIARKMGFP EIILPGDVRN DIYVTLIHGE FDKGKKKTPK NVEVTMSVHD EEGKLLEKAI
HPGAGYEGIS EYKSVVYYQV KQPCWYETVK VSIAIEEVTR CHIRFTFRHR SSQESKDKSE
RAFGVAFVKL MNPDGTTLQD GRHDLVVYKG DNKKMEDAKF YLTLPGTKME MEEKELQASK
NLVTFTPSKD STKDSFQIAT LICSTKLTQN VDLLGLLNWR SNSQNIKHNL KKLMEVDGGE
IVKFLQDTLD ALFNIMMEMS DSETYDFLVF DALVFIISLI GDIKFQHFNP VLETYIYKHF
SATLAYVKLS KVLNFYVANA DDSSKTELLF AALKALKYLF RFIIQSRVLY LRFYGQSKDG
DEFNNSIRQL FLAFNMLMDR PLEEAVKIKG AALKYLPSII NDVKLVFDPV ELSVLFCKFI
QSIPDNQLVR QKLNCMTKIV ESTLFQQSEC REVLLPLLTD QLSGQLDDNS SKPDHEASSQ
LLSNILEVLD RKDVGATAMH IQLIMERLLR RINRTVIGMN RQSPHIGSFV ACMIALLQQM
DDSHYSHYIS TFKTRQDIID FLMETFIMFK DLIGKNVYAK DWMVMNMTQN RVFLRAINQF
AEVLTRFFMD QASFELQLWN NYFHLAVAFL THESLQLETF SQAKRNKIVK NNFLISSFTF
ISGPHKIKFI PSMVGPILEV TLTPEVELRK ATIPIFFDMM QCEFNFSGNG NFHMFENELI
TKLDQEVEGG RGDEQYKVLL EKLLLEHCRK HKYLSSSGEV FALLVSSLLE NLLDYRTIIM
QDESKENRMS CTVNVLNFYK EKKREDIYIR YLYKLRDLHR DCENYTEAAY TLLLHAELLQ
WSDKPCVPHL LQRDSYYVYT QQELKEKLYQ EIISYFDKGK MWEKAIKLSK ELAETYESKV
FDYEGLGNLL KKRASFYENI IKAMRPQPEY FAVGYYGQGF PSFLRNKIFI YRGKEYERRE
DFSLRLLTQF PNAEKMTSTT PPGEDIKSSP KQYMQCFTVK PVMSLPPSYK DKPVPEQILN
YYRANEVQQF RYSRPFRKGE KDPENEFATM WIERTTYTTA YTFPGILKWF EVKQISTEEI
SPLENAIETM ELTNERISNC VQQHAWDRSL SVHPLSMLLS GIVDPAVMGG FSNYEKAFFT
EKYLQEHPED QEKVELLKQL IALQMPLLTE GIRIHGEKLT EQLKPLHERL SSCFRELKEK
VEKHYGVITL PPNLTERKQS RTGSIVLPYI MSSTLRRLSI TSVTSSVVST SSNSSDNAPS
RPGSDGSILE PLLERRASSG ARVEDLSLRE ENSENRISKF KRKDWSLSKS QVIAEKAPEP
DLMSPTRKAQ RPKSLQLMDN RLSPFHGSSP PQSTPLSPPP LTPKATRTLS SPSLQTDGIA
ATPVPPPPPP KSKPYEGSQR NSTELAPPLP VRREAKAPPP PPPKARKSGI STSEPGSQ
//