ID G1S2K8_NOMLE Unreviewed; 471 AA.
AC G1S2K8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Tripartite motif containing 72 {ECO:0000313|Ensembl:ENSNLEP00000019746.2};
GN Name=TRIM72 {ECO:0000313|Ensembl:ENSNLEP00000019746.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000019746.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000019746.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000019746.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01124656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01124657; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1S2K8; -.
DR STRING; 61853.ENSNLEP00000019746; -.
DR Ensembl; ENSNLET00000020739.2; ENSNLEP00000019746.2; ENSNLEG00000016280.2.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000161791; -.
DR HOGENOM; CLU_013137_0_3_1; -.
DR InParanoid; G1S2K8; -.
DR OMA; ECVEHKQ; -.
DR TreeFam; TF342569; -.
DR Proteomes; UP000001073; Chromosome 2.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
DR GO; GO:0042383; C:sarcolemma; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0001786; F:phosphatidylserine binding; IEA:Ensembl.
DR GO; GO:0031624; F:ubiquitin conjugating enzyme binding; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0007517; P:muscle organ development; IEA:Ensembl.
DR GO; GO:0003012; P:muscle system process; IEA:Ensembl.
DR GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0043569; P:negative regulation of insulin-like growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0010832; P:negative regulation of myotube differentiation; IEA:Ensembl.
DR GO; GO:0001778; P:plasma membrane repair; IEA:Ensembl.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
DR CDD; cd16612; RING-HC_TRIM72_C-IV; 1.
DR CDD; cd13742; SPRY_PRY_TRIM72; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR PANTHER; PTHR24103:SF11; TRIPARTITE MOTIF-CONTAINING PROTEIN 72; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 14..57
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 265..469
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
SQ SEQUENCE 471 AA; 52060 MW; 3655FF583416832E CRC64;
MSAAPGLLHQ ELSCPLCLQL FDAPVTAECG HSFCRACLGR VAGEPAADGT VLCPCCQAPT
RPQALSTNLQ LARLVEGLAQ VPQGHCEEHL DPLSIYCEQD LCASLGSHRG HRLLPAAEAH
ARLKTQLPQQ KLQLQEACMR KEKSVAVLEH QLVEVEETVR QFRGAVGEQL GKMRVFLAAL
EGSLDREAER VRGEAGVALR RELGSLNSYL EQLRQMEKVL EEVADKPQTE FLMKYCLVTS
RLQKILAESP PPARLDIQLP IISDDFKFQV WRKMFRALMP ALEELTFDPS SAHPSLVVSS
SGRRVECSEQ KAPPAGEDPR QFDKAVAVVA HQQLSEGEHY WEVEVGDKPR WALGVIAAEA
PRRGRLHAVP SQGLWLLGLR EGKILEAHVE AKEPRALRSP ERRPTRIGLY LSFGDGVLSF
YDASDADALV PLFAFHERLP GPVYPFFDVC WHDKGKNAQP LLLVGPEGAE A
//
