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Database: UniProt
Entry: G1S2P3_NOMLE
LinkDB: G1S2P3_NOMLE
Original site: G1S2P3_NOMLE 
ID   G1S2P3_NOMLE            Unreviewed;       514 AA.
AC   G1S2P3;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   31-JUL-2019, entry version 57.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000019781};
GN   Name=CHRNA2 {ECO:0000313|Ensembl:ENSNLEP00000019781};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000019781, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000019781}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000019781}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
CC       membrane {ECO:0000256|SAAS:SAAS00569352}; Multi-pass membrane
CC       protein {ECO:0000256|SAAS:SAAS00569352}. Cell membrane
CC       {ECO:0000256|SAAS:SAAS00569391}; Multi-pass membrane protein
CC       {ECO:0000256|SAAS:SAAS00569391}.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00978283}.
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DR   EMBL; ADFV01074198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01074199; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004088729.1; XM_004088681.1.
DR   STRING; 61853.ENSNLEP00000019781; -.
DR   Ensembl; ENSNLET00000020776; ENSNLEP00000019781; ENSNLEG00000016309.
DR   GeneID; 100585295; -.
DR   CTD; 1135; -.
DR   eggNOG; KOG3645; Eukaryota.
DR   eggNOG; ENOG410XQGR; LUCA.
DR   GeneTree; ENSGT00940000158299; -.
DR   InParanoid; G1S2P3; -.
DR   OrthoDB; 381858at2759; -.
DR   TreeFam; TF315605; -.
DR   Proteomes; UP000001073; Chromosome 8.
DR   GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00254; NICOTINICR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   TIGRFAMs; TIGR00860; LIC; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|SAAS:SAAS00458005};
KW   Cell membrane {ECO:0000256|SAAS:SAAS00458000};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00081591};
KW   Ion channel {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00458066};
KW   Ion transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457919};
KW   Ligand-gated ion channel {ECO:0000256|SAAS:SAAS00172123};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Postsynaptic cell membrane {ECO:0000256|SAAS:SAAS00081626};
KW   Receptor {ECO:0000256|SAAS:SAAS00172128};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Synapse {ECO:0000256|SAAS:SAAS00103537};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00081549}.
FT   SIGNAL        1     29       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        30    514       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014164586.
FT   TRANSMEM    251    275       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    282    304       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    316    337       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    488    510       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       60    249       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   DOMAIN      257    505       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
FT   REGION       27     55       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   514 AA;  58109 MW;  1B76A98252AFD0D1 CRC64;
     MGPSCPVFVS FTKLSLWWLL LTPAGGEEAK RPPPRAPGDP LSSPSPTALP QGGSHTEAED
     RLFKHLFRGY NRWARPVPNT SDVDEKNQMM TTNVWLKQEW SDYKLRWNPA DFGNITSLRV
     PSEMIWIPDI VLYNNADGEF AVTHMTKAHL FSTGTVHWVP PAIYKSSCSI DVTFFPFDQQ
     NCKMKFGSWT YDKAKIDLEQ MEQTVDLKDY WESGEWAIVN ATGTYNSKKY DCCAEIYPDV
     TYAFVIRRLP LFYTINLIIP CLLISCLTVL VFYLPSDCGE KITLCISVLL SLTVFLLLIT
     EIIPSTSLVI PLIGEYLLFT MIFVTLSIVI TVFVLNVHHR SPSTHTMPRW VRGALLGCVP
     RWLLMNRPPP PLELCRPPRL KLSPSYHWLE SNVDAEEREV VVEEEDRWAC AGHAAPSVGT
     LCSHGHLHSG ASGPKAETVL QEGELLLSPR MQKALEGVHY IADHLRSEDA DSSVKEDWKY
     VAMVIDRIFL WLFIIVCFLG TIGLFLPPFL AGMI
//
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