ID G1S328_NOMLE Unreviewed; 499 AA.
AC G1S328;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Cytochrome P450 family 4 subfamily A member 11 {ECO:0008006|Google:ProtNLM};
GN Name=LOC100588910 {ECO:0000313|Ensembl:ENSNLEP00000019916.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000019916.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000019916.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000019916.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; ADFV01185436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01185437; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01185438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1S328; -.
DR STRING; 61853.ENSNLEP00000019916; -.
DR Ensembl; ENSNLET00000020915.2; ENSNLEP00000019916.2; ENSNLEG00000016409.3.
DR eggNOG; KOG0157; Eukaryota.
DR GeneTree; ENSGT00940000163504; -.
DR HOGENOM; CLU_001570_5_1_1; -.
DR InParanoid; G1S328; -.
DR OMA; IQPAFRL; -.
DR TreeFam; TF105088; -.
DR Proteomes; UP000001073; Chromosome 12.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd20678; CYP4B-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24291:SF39; CYTOCHROME P450 4A11-RELATED; 1.
DR PANTHER; PTHR24291; CYTOCHROME P450 FAMILY 4; 1.
DR Pfam; PF00067; p450; 2.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 499 AA; 57507 MW; 57E0DC0001A3523D CRC64;
MSVSVLSPSR LLGGVSGILQ AASLLILLLL LIKAAQLYLH RQWLLKALQQ FPCPPSHWLF
GHIQEFQEDQ ELQQTRKWVE TFPSACPRWL WGGKVRVQLY DPDYMKVILG RSDPKSHGSY
RFLAPWIGYG LLLLNGQTWF QHRRMLTPAF HYDILKPYVG LMADSVRVML DKWEKLLGQE
DSPLEVFQHI SLMTLDTIMK CAFSHQGSIQ VDRNSQSYIQ AIRDLNDLLF SRVRNAFYQN
DTIYSLTSAG RWTHRACQLA HQYTDQVVQL RKAQLQKEGE LEKIKRKRHL DFLDILLLAK
MENGSILSDK DLRAEVDTFM FEGHDTTASG ISWIFYALAT HPKHQERCRE EIHGLLGDGA
SITWNHLDQM PYTTMCIRRH CHPMQMIGIM VVLSIYGLHY NPKVWPNPEV FDPFRFAPGS
AQHSHAFLPF SGGSRNCIGK QFAMNELKVA TALTLLRFEL LPDPTRTPIP MARLVLKSKN
GIHLRLRRLP NPCEDKDQL
//
