ID G1S3E2_NOMLE Unreviewed; 625 AA.
AC G1S3E2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Enolase 4 {ECO:0000256|ARBA:ARBA00034855};
DE EC=4.2.1.11 {ECO:0000256|ARBA:ARBA00012058};
DE AltName: Full=2-phospho-D-glycerate hydro-lyase {ECO:0000256|ARBA:ARBA00031125};
GN Name=ENO4 {ECO:0000313|Ensembl:ENSNLEP00000020030.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000020030.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000020030.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000020030.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC glyceraldehyde 3-phosphate: step 4/5. {ECO:0000256|ARBA:ARBA00005031}.
CC -!- SIMILARITY: Belongs to the enolase family.
CC {ECO:0000256|ARBA:ARBA00009604}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01164295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01164296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01164297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003255049.2; XM_003255001.3.
DR AlphaFoldDB; G1S3E2; -.
DR Ensembl; ENSNLET00000021034.2; ENSNLEP00000020030.2; ENSNLEG00000016516.2.
DR GeneID; 100584866; -.
DR KEGG; nle:100584866; -.
DR CTD; 387712; -.
DR eggNOG; KOG2670; Eukaryota.
DR GeneTree; ENSGT00950000182805; -.
DR HOGENOM; CLU_493979_0_0_1; -.
DR OrthoDB; 2908712at2759; -.
DR TreeFam; TF354238; -.
DR UniPathway; UPA00109; UER00187.
DR Proteomes; UP000001073; Chromosome 3.
DR GO; GO:0000015; C:phosphopyruvate hydratase complex; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0004634; F:phosphopyruvate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR CDD; cd22974; DD_ENO4; 1.
DR Gene3D; 3.20.20.120; Enolase-like C-terminal domain; 1.
DR Gene3D; 3.30.390.10; Enolase-like, N-terminal domain; 1.
DR InterPro; IPR047500; DD_ENO4.
DR InterPro; IPR000941; Enolase.
DR InterPro; IPR036849; Enolase-like_C_sf.
DR InterPro; IPR029017; Enolase-like_N.
DR InterPro; IPR020810; Enolase_C.
DR InterPro; IPR020811; Enolase_N.
DR PANTHER; PTHR11902; ENOLASE; 1.
DR PANTHER; PTHR11902:SF30; ENOLASE 4; 1.
DR Pfam; PF00113; Enolase_C; 1.
DR SMART; SM01192; Enolase_C; 1.
DR SMART; SM01193; Enolase_N; 1.
DR SUPFAM; SSF51604; Enolase C-terminal domain-like; 1.
DR SUPFAM; SSF54826; Enolase N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 68..261
FT /note="Enolase N-terminal"
FT /evidence="ECO:0000259|SMART:SM01193"
FT DOMAIN 273..582
FT /note="Enolase C-terminal TIM barrel"
FT /evidence="ECO:0000259|SMART:SM01192"
FT REGION 176..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..206
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 625 AA; 68458 MW; 9CE3221C706C79EF CRC64;
MGEEGGGRSC GTTRELQKLK QQAMEYYREN DVPRRLEELL NSTFYLQPAD VYGHLANCFS
KLAKPPTICK IVGKEVLDGL GLPTLQVDIF CTIQNFPKNI CSVVISTHFE VHENALPELA
EAEEAERASA VSTAVQWVNG TITHELQGMA PSDQAEVDHL LRIFFASKVQ EDKERKELEK
SLEYSTVPSP LPPVPPPPPP PPPTKKKGQK PARKDTITEK PIAPAEPVEP ILSGSMAIGA
VSLAVAKACA MLLNKPLYLS IALLKHNQEQ PTTLSMPLLM VSLVSCGKSS SGKLNLMKEV
ICIPHPELTT KQGVEMLMEI QKHINKIIEM PSPPKAETKK GHDGSKRGQQ QITGKMSHLG
CLTINCDSIE QPLLLIQEVC ANLGLELGTN LHLAINCAGH ELMDYNKGKY EVIMGTYKNA
AEMVDLYVDL INKYPSIIAL IDPFRKEDSE QWDSICHALG SRCYIIAGTA SKSISKLLEQ
GNISIPKSNG LIIKHTNQTT MSDLVEITNL IDSKKHITVF GSTEGESSDD SLVDLAVGLG
VRFIKLGGLS RGERVTKYNR LLTIEEELVQ NRTLGFKEEH TFFYFNEEAE KAAEALEAAA
AREPLVPTFP TQGVEESAET GASSG
//