ID G1S3K0_NOMLE Unreviewed; 348 AA.
AC G1S3K0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Potassium two pore domain channel subfamily K member 18 {ECO:0000313|Ensembl:ENSNLEP00000020088.2};
GN Name=KCNK18 {ECO:0000313|Ensembl:ENSNLEP00000020088.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000020088.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000020088.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000020088.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
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DR EMBL; ADFV01164314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1S3K0; -.
DR STRING; 61853.ENSNLEP00000020088; -.
DR Ensembl; ENSNLET00000021094.2; ENSNLEP00000020088.2; ENSNLEG00000016567.2.
DR eggNOG; KOG1418; Eukaryota.
DR GeneTree; ENSGT00700000104522; -.
DR HOGENOM; CLU_022504_5_3_1; -.
DR InParanoid; G1S3K0; -.
DR OMA; RWSSCPE; -.
DR TreeFam; TF316115; -.
DR Proteomes; UP000001073; Chromosome 3.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0015269; F:calcium-activated potassium channel activity; IEA:Ensembl.
DR GO; GO:0015271; F:outward rectifier potassium channel activity; IEA:Ensembl.
DR GO; GO:0071467; P:cellular response to pH; IEA:Ensembl.
DR GO; GO:0097623; P:potassium ion export across plasma membrane; IEA:Ensembl.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003:SF291; POTASSIUM CHANNEL SUBFAMILY K MEMBER 18; 1.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 66..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..120
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 253..326
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
SQ SEQUENCE 348 AA; 39714 MW; C43A7DE1895BB765 CRC64;
VGAVLFSAIE DGQVLVAADD GEFEKFLEEL CRILNCSETV VEDRKQDLQG HLQKVKPQWF
NRTANWSFVS SLFFCCTVFS TVGYGYIYPV TRLGKYLCML YALFGIPLMF LVLTDTGDIL
ATILSTSYNQ FRKFPFFTRP LLSKWCPKSL KKKPDPKPTD EAVPQIIISA EELPGPKLGI
CPSRPSCSME LFERPHAREK QNTLQLPPQA MERSNSCPEL VLGRLSYSII SNLDEVGQQV
ERLDIPLPII ALIVFAYISC AAAILPFWET QLDFENAFYF CFVTLTTIGF GDTVLEHPNF
FLFFSIYIII GMEIVFIAFK LVQNRLIDIY KNVMLFFAKG KFYHLDKK
//
