ID   G1S3W2_NOMLE            Unreviewed;       523 AA.
AC   G1S3W2;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   SubName: Full=Synaptotagmin 10 {ECO:0000313|Ensembl:ENSNLEP00000020200.1};
GN   Name=SYT10 {ECO:0000313|Ensembl:ENSNLEP00000020200.1};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000020200.1, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000020200.1, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000020200.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the synaptotagmin family.
CC       {ECO:0000256|ARBA:ARBA00006996}.
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DR   EMBL; ADFV01103508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01103509; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003277856.1; XM_003277808.2.
DR   AlphaFoldDB; G1S3W2; -.
DR   STRING; 61853.ENSNLEP00000020200; -.
DR   Ensembl; ENSNLET00000021209.2; ENSNLEP00000020200.1; ENSNLEG00000016653.2.
DR   GeneID; 100581223; -.
DR   KEGG; nle:100581223; -.
DR   CTD; 341359; -.
DR   eggNOG; KOG1028; Eukaryota.
DR   GeneTree; ENSGT00940000158899; -.
DR   HOGENOM; CLU_023008_8_3_1; -.
DR   InParanoid; G1S3W2; -.
DR   OMA; IWKDIHC; -.
DR   OrthoDB; 590187at2759; -.
DR   TreeFam; TF315600; -.
DR   Proteomes; UP000001073; Chromosome 23.
DR   GO; GO:0070382; C:exocytic vesicle; IEA:Ensembl.
DR   GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0098793; C:presynapse; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR   GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Ensembl.
DR   GO; GO:0001786; F:phosphatidylserine binding; IEA:Ensembl.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0000149; F:SNARE binding; IEA:Ensembl.
DR   GO; GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
DR   GO; GO:0099525; P:presynaptic dense core vesicle exocytosis; IEA:Ensembl.
DR   GO; GO:0007608; P:sensory perception of smell; IEA:Ensembl.
DR   CDD; cd08385; C2A_Synaptotagmin-1-5-6-9-10; 1.
DR   CDD; cd08403; C2B_Synaptotagmin-3-5-6-9-10; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 2.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR001565; Synaptotagmin.
DR   PANTHER; PTHR10024; SYNAPTOTAGMIN; 1.
DR   PANTHER; PTHR10024:SF46; SYNAPTOTAGMIN-10; 1.
DR   Pfam; PF00168; C2; 2.
DR   PRINTS; PR00360; C2DOMAIN.
DR   PRINTS; PR00399; SYNAPTOTAGMN.
DR   SMART; SM00239; C2; 2.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR   PROSITE; PS50004; C2; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        52..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          231..352
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          363..496
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
SQ   SEQUENCE   523 AA;  59053 MW;  470C2E1CB9F7658E CRC64;
     MSFHKEDGVN SLCQKALHIV TELCFAGQVE WEKCAGIFPR DRGSQGGSST DISVSLLAVV
     VSFCGLALLV VSLFVFWKLC WPCWKSKPVT TNVTTLPQSI SSAPTEVFET EEKKEIKENE
     KPAVKAIEPA IKISHTSPDI PAEVQTALKE HLIKHARVQR QITEPTSSSR HNSFRRHLPR
     QMQVSSVDFS MGTEPVLQRG GTTTSIGRIK PELYKQRSVD SEGSQKEDVK ICGKLNFTLQ
     YDYENELLVV NIIKALDLPA KDFTGTSDPY VKMYLLPDRK KKFQTRVHRK TLNPLFDETF
     QFPVAYDQLS NRKLHFSVYD FDRFSRHDMI GEVILDNLFE VSDLSREATV WKDIHCATTE
     SIDLGEIMFS LCYLPTAGRM TLTVIKCRNL KAMDITGSSD PYVKVSLMCE GRRLKKRKTT
     TKKNTLNPVY NEAIIFDIPP ENVDQVSLSI AVMDYDRVGH NEVIGVCRTG LDAEGLGRDH
     WNEMLAYHRK PITHWHPLLE LPGRATSFDS QGSCPSPKPP STP
//