ID G1S489_NOMLE Unreviewed; 1320 AA.
AC G1S489;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 3.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Adhesion G protein-coupled receptor A3 {ECO:0000313|Ensembl:ENSNLEP00000020327.3};
GN Name=ADGRA3 {ECO:0000313|Ensembl:ENSNLEP00000020327.3};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000020327.3, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000020327.3, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000020327.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR EMBL; ADFV01181818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01181819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01181820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003258580.1; XM_003258532.2.
DR STRING; 61853.ENSNLEP00000020327; -.
DR Ensembl; ENSNLET00000021342.3; ENSNLEP00000020327.3; ENSNLEG00000016741.3.
DR GeneID; 100587353; -.
DR KEGG; nle:100587353; -.
DR CTD; 166647; -.
DR eggNOG; KOG0619; Eukaryota.
DR eggNOG; KOG4237; Eukaryota.
DR GeneTree; ENSGT00940000157235; -.
DR HOGENOM; CLU_005242_1_0_1; -.
DR InParanoid; G1S489; -.
DR OMA; CQQHYQH; -.
DR OrthoDB; 2900279at2759; -.
DR TreeFam; TF331206; -.
DR Proteomes; UP000001073; Chromosome 20.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45930:SF2; ADHESION G PROTEIN-COUPLED RECEPTOR A3; 1.
DR PANTHER; PTHR45930; G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..37
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 38..1320
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014130004"
FT TRANSMEM 761..782
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 794..815
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 827..850
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 876..896
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 916..939
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 995..1018
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1024..1043
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 241..339
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 322..417
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 755..943
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1072..1093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1197..1267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1296..1320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1197..1212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1229..1255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1320 AA; 146202 MW; 6C20153222E0D7C0 CRC64;
MEPPGRRRGR AQPPLRLPLS LLALLALLGG GGGGAAALPA GCKHDGRPRG AGRAAGAAEG
KVVCSSLELA QVLPPDTLPN RTVTLILSNN KISELKNGSF SGLSLLERLD LRNNLISSID
PGAFWGLSSL KRLDLTNNRI GCLNADIFRG LTNLVRLNLS GNLFSSLSQG TFEYLASLRS
LEFQTEYLLC DCNILWMHRW VKERNITVRD TRCVYPKSLQ AQPVTGVKQE LLTCDPPLEL
PSFYMTPSHR QVVFEGDSLP FQCMASYIDQ DMQVLWYQDG RIVETDESQG IFVEKNMIHN
CSLIASALTI SNIQAGSTGN WGCHVQTKRG NNTRTVDIVV LESSAQYCPP ERVVNNKGDF
RWPRTLAGIT AYLQCTRNTH GSGIYPGNPQ DERKAWRRCD RGGFWADDDY SRCQYANDVT
RVLYMFNQMP LNLTNAVATA RQLLAYTVEA ANFSDKMDVI FVAEMIEKFG RFTKEEKSKE
LGDVMVDIAS NIMLADERVL WLAQREAKAC SRIVQCLQRI ATYRLAGGAH VYSTYSPNIA
LEAYVIKSTG FTGMTCTVFQ KVAASDRTGL SDYGRRDPDG NLDKQLSFKC NVSNTFSSLA
LKNTIVEASI QLPPSLFSPK QKRELRPTDD SLYKLQLIAF RNGKLFPATG NSTNLADDGK
RRTVVTPVIL TKIDGVNVDT HHIPVNVTLR RIAHGADAVA ARWDFDLLNG QGGWKSDGCH
ILYSDENITT IQCYSLSNYA VLMDLTGSEL YTQAASLLHP VVYTTAIILL LCLLAVIVSY
IYHHSLIRIS LKSWHMLVNL CFHIFLTCVV FVGGITQTRN ASVCQAVGII LHYSTLATVL
WVGVTARNIY KQVTKKAKRC QDPDEPPPPP RPMLRFYLIG GGIPIIVCGI TAAANIKNYG
SRPNAPYCWM AWEPSLGAFY GPASFITFVN CMYFLSIFIQ LKRHPERKYE LKEPTEEQQR
LAANENGEIN HQDSMSLSLI STSALENEHT FHSQLLGASL TLLLYVALWM FGALAVSLYY
PLDLVFSFIF GATCLSFSAF FMVHHCVNRE DVRLAWIMTC CPGRSSYSVQ VNVQPPNSSG
TNGEAPKCPN SSAESSCTNK SASSFKNSSQ GCKLTNLQAA AAQCHANSLP LNSTPQLDNS
LTEHSMDNDI KMHVAPLEVQ FRTNVHSSRH HKNRSKGHRA SRLTVLREYA YDVPTSVEGS
VQNGLPKSRL GNNEGHSRSR RTYLAYRERQ YNPPQQDSSD ACSTLPKSSR NFEKPVSTSS
KKDALRKPAV VELENQQKSY GLNLAIQNGP IKSNGQEGPL LGTDSTGNVR TGLWKHETTV
//