ID G1S4I2_NOMLE Unreviewed; 420 AA.
AC G1S4I2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Vascular endothelial growth factor C {ECO:0000313|Ensembl:ENSNLEP00000020420.2};
GN Name=VEGFC {ECO:0000313|Ensembl:ENSNLEP00000020420.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000020420.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000020420.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000020420.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC {ECO:0000256|ARBA:ARBA00006686, ECO:0000256|RuleBase:RU003818}.
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DR EMBL; ADFV01096576; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01096577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01096578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01096579; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01096580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01096581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01096582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01096583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1S4I2; -.
DR STRING; 61853.ENSNLEP00000020420; -.
DR Ensembl; ENSNLET00000021436.2; ENSNLEP00000020420.2; ENSNLEG00000016806.2.
DR eggNOG; ENOG502QVXE; Eukaryota.
DR GeneTree; ENSGT00940000156167; -.
DR HOGENOM; CLU_061712_1_0_1; -.
DR InParanoid; G1S4I2; -.
DR OMA; ALPQCQA; -.
DR TreeFam; TF319554; -.
DR Proteomes; UP000001073; Chromosome 7b.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0042056; F:chemoattractant activity; IEA:Ensembl.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0043185; F:vascular endothelial growth factor receptor 3 binding; IEA:Ensembl.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0014009; P:glial cell proliferation; IEA:Ensembl.
DR GO; GO:0050930; P:induction of positive chemotaxis; IEA:Ensembl.
DR GO; GO:0016331; P:morphogenesis of embryonic epithelium; IEA:Ensembl.
DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0060252; P:positive regulation of glial cell proliferation; IEA:Ensembl.
DR GO; GO:1901492; P:positive regulation of lymphangiogenesis; IEA:Ensembl.
DR GO; GO:0060754; P:positive regulation of mast cell chemotaxis; IEA:Ensembl.
DR GO; GO:1902462; P:positive regulation of mesenchymal stem cell proliferation; IEA:Ensembl.
DR GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:Ensembl.
DR CDD; cd00135; PDGF; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR004153; CXCXC_repeat.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR023581; PD_growth_factor_CS.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR PANTHER; PTHR12025; VASCULAR ENDOTHELIAL GROWTH FACTOR; 1.
DR PANTHER; PTHR12025:SF3; VASCULAR ENDOTHELIAL GROWTH FACTOR C; 1.
DR Pfam; PF03128; CXCXC; 3.
DR Pfam; PF00341; PDGF; 1.
DR SMART; SM00141; PDGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00249; PDGF_1; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|RuleBase:RU003818};
KW Mitogen {ECO:0000256|ARBA:ARBA00023246};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..420
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014185634"
FT DOMAIN 116..215
FT /note="Platelet-derived growth factor (PDGF) family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50278"
SQ SEQUENCE 420 AA; 47204 MW; A76673C71B6816C7 CRC64;
MHLLGFFSLA CSLLAAALLP GPREAPAAAA FESGLDLSDA EPDAGEATAY ASKDLEEQLR
SVSSVDELMT VLYPEYWKMY KCQLRKGGWQ HNREQANLNS RTEETIKFAA AHYNTEILKS
IDNEWRKTQC MPREVCIDVG KEFGVATNTF FKPPCVSIYR CGGCCNSEGL QCMNTSTSYL
SKTLFEITVP LSQGPKPVTI SFANHTSCRC MSKLDVYRQV HSIIRRSLPA TLPQCQAVNK
TCPTNYMWNN HICRCLSQED FMFSSDAGDG KQNDMDFHDI CGPNKELDEE TCQCVCRSGL
RPASCGPHKE LDRNSCQCVC KNKLFPSQCG ANREFDENTC QCVCKRTCPR NQPLNPGKCA
CECTESSQKC LLKGKKFHHQ TCSCYRRPCT NRQKACEPGF SYSEEVCRCV PSYWKRPQMS
//
