ID G1S4S5_NOMLE Unreviewed; 543 AA.
AC G1S4S5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Potassium two pore domain channel subfamily K member 10 {ECO:0000313|Ensembl:ENSNLEP00000020513.1};
GN Name=KCNK10 {ECO:0000313|Ensembl:ENSNLEP00000020513.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000020513.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000020513.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000020513.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
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DR EMBL; ADFV01193217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01193218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01193219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01193220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01193221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01193222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01193223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01193224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01193225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01193226; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003260902.1; XM_003260854.3.
DR AlphaFoldDB; G1S4S5; -.
DR SMR; G1S4S5; -.
DR Ensembl; ENSNLET00000021533.2; ENSNLEP00000020513.1; ENSNLEG00000016891.2.
DR GeneID; 100588245; -.
DR KEGG; nle:100588245; -.
DR CTD; 54207; -.
DR eggNOG; KOG1418; Eukaryota.
DR GeneTree; ENSGT00940000156147; -.
DR HOGENOM; CLU_022504_10_0_1; -.
DR OrthoDB; 600333at2759; -.
DR TreeFam; TF313947; -.
DR Proteomes; UP000001073; Chromosome 22a.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR003976; 2pore_dom_K_chnl_TREK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003:SF32; POTASSIUM CHANNEL SUBFAMILY K MEMBER 10; 1.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR PRINTS; PR01499; TREKCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 77..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 152..210
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 249..328
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 27..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..543
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 543 AA; 60369 MW; B048D5F6F076444D CRC64;
MKFPIETPRK QVNWDPKVAV PAAAPVCQPK SATNGQPPAP APTPTPRLSI SSRATVVARM
EGTSQGGLQT VMKWKTVVAI FVVVVVYLVT GGLVFRALEQ PFESSQKNTI ALEKAEFLRD
HVCVSPQELE TLIQHALDAD NAGVSPIGNS SNNSSHWDLG SAFFFAGTVI TTIGYGNIAP
STEGGKIFCI LYAIFGIPLF GFLLAGIGDQ LGTIFGKSIA RVEKVFRKKQ VSQTKIRVIS
TILFILAGCI VFVTIPAVIF KYIEGWTALE SIYFVVVTLT TVGFGDFVAG GNAGINYREW
YKPLVWFWIL VGLAYFAAVL SMIGDWLRVL SKKTKEEVGE IKAHAAEWKA NVTAEFRETR
RRLSVEIHDK LQRAATIRSM ERRRLGLDQR AHSLDMLSPE KRSVFAALDT GRFKASSQES
INNRPNNLRL KGPEQLNKHG QGASEDNIIN KFGSTSRLTK RKNKDLKKTL PEDVQKIYKT
FRNYSLDEEK KEEETEKMCN SDNSSTAMLT DCIQQHAEME NGMIPTDTKD RELENNSLLE
DRN
//
