ID G1S5H7_NOMLE Unreviewed; 454 AA.
AC G1S5H7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Myb/SANT-like DNA-binding domain-containing protein 3 {ECO:0000256|ARBA:ARBA00021372};
GN Name=TMEFF1 {ECO:0000313|Ensembl:ENSNLEP00000020765.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000020765.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000020765.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000020765.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the MSANTD3 family.
CC {ECO:0000256|ARBA:ARBA00007954}.
CC -!- SIMILARITY: Belongs to the tomoregulin family.
CC {ECO:0000256|ARBA:ARBA00038484}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; ADFV01190723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01190724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01190725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01190726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01190727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01190728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01190729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01190730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01190731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01190732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003260339.1; XM_003260291.2.
DR AlphaFoldDB; G1S5H7; -.
DR STRING; 61853.ENSNLEP00000020765; -.
DR Ensembl; ENSNLET00000021805.3; ENSNLEP00000020765.2; ENSNLEG00000017101.3.
DR eggNOG; KOG3649; Eukaryota.
DR GeneTree; ENSGT00940000160714; -.
DR HOGENOM; CLU_048579_1_0_1; -.
DR InParanoid; G1S5H7; -.
DR OMA; DSTCRYG; -.
DR TreeFam; TF330868; -.
DR Proteomes; UP000001073; Chromosome 1a.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00104; KAZAL_FS; 2.
DR Gene3D; 3.30.60.30; -; 2.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR028002; Myb_DNA-bind_5.
DR PANTHER; PTHR21632:SF3; TOMOREGULIN-1; 1.
DR PANTHER; PTHR21632; UNCHARACTERIZED; 1.
DR Pfam; PF07648; Kazal_2; 2.
DR Pfam; PF13873; Myb_DNA-bind_5; 1.
DR SMART; SM00280; KAZAL; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 2.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS51465; KAZAL_2; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 404..426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 172..219
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 263..311
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 345..385
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 221..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 375..384
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 454 AA; 50970 MW; 140539BD7F824952 CRC64;
MQNNEIIKPA KYFSELEKSI LLALVEKYKY VLECKKSDAR TIALKQRTWQ ALAHEYNSQP
SVSLRDFKQL KKCWENIKAR TKKIMAHERR EKVKRSVSPL LSTHVLGKEK IASMLPEQLY
FLQSPPEEEP EYHPDASAQE LNVRESDVRV CDESSCKYGG VCKEDGDGLK CACQFQCHTN
YIPVCGSNGD TYQNECFLRR AACKHQKEIT VVARGPCYSD NGSGSGEGEE EGSGAEVHRK
HSKCGPCKYK AECDEDAENV GCVCNIDCSG YSFNPVCASD GSSYNNPCFV REASCIKQEQ
IDIRHLGHCT DTDDTSLLGK KDDGLQYRPD VKDASDQRED VYIGNHMPCP ENLNGYCIHG
KCEFIYSTQK ASCRCESGYT GQHCEKTDFS ILYVVPSRQK LTHVLIAAII GAVQIAIIVA
IVMCITRKCP KNNRGRRQKQ NLGHFTSDTS SRMV
//
