ID G1S8F3_NOMLE Unreviewed; 345 AA.
AC G1S8F3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Low density lipoprotein receptor class A domain containing 3 {ECO:0000313|Ensembl:ENSNLEP00000021792.1};
GN Name=LDLRAD3 {ECO:0000313|Ensembl:ENSNLEP00000021792.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000021792.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000021792.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000021792.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; ADFV01113450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01113451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01113452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01113453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01113454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01113455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01113456; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01113457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01113458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01113459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1S8F3; -.
DR SMR; G1S8F3; -.
DR STRING; 61853.ENSNLEP00000021792; -.
DR Ensembl; ENSNLET00000022892.3; ENSNLEP00000021792.1; ENSNLEG00000017940.3.
DR eggNOG; KOG1215; Eukaryota.
DR GeneTree; ENSGT00940000160574; -.
DR HOGENOM; CLU_072228_0_0_1; -.
DR InParanoid; G1S8F3; -.
DR OMA; RNGHCVD; -.
DR OrthoDB; 3145218at2759; -.
DR TreeFam; TF332096; -.
DR Proteomes; UP000001073; Chromosome 15.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0001540; F:amyloid-beta binding; IEA:Ensembl.
DR GO; GO:0006898; P:receptor-mediated endocytosis; IEA:Ensembl.
DR GO; GO:0070613; P:regulation of protein processing; IEA:Ensembl.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270:SF24; LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR Pfam; PF00057; Ldl_recept_a; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00192; LDLa; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..345
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003420886"
FT TRANSMEM 172..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 270..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 37..55
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 49..64
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 91..106
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 113..125
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 120..138
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 132..147
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 345 AA; 37419 MW; 3EB6CADDC5EE9CC4 CRC64;
MWLLGPLCLL LSSAAESQLL PGNNFTNECN IPGNFMCSNG RCIPGAWQCD GLPDCFDKSD
EKECPKAKSK CGPTFFPCAS GIHCIIGRFR CNGFEDCPDG SDEENCTANP LLCSTARYHC
KNGLCIDKSF ICDGQNNCQD NSDEESCESS QEPGSGQVFV TSENQLVYYP SITYAIIGSS
VIFVLVVALL ALVLHHQRKR NNLMTLPVHR LQHPVLLSRL VVLDHPHHCN VTYNVNNGIQ
YVASQAEQNA SEVGSPPSYS EALLDQRPAW YDLPPPPYSS DTESLNQADL PPYRSRSGSA
NSASSQAASS LLSVEDTSHS PGQPGPQEGT AEPRDSEPSQ GTEEV
//
