ID G1SCU7_RABIT Unreviewed; 1161 AA.
AC G1SCU7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Period circadian protein homolog 2 {ECO:0000256|ARBA:ARBA00039684};
DE AltName: Full=Circadian clock protein PERIOD 2 {ECO:0000256|ARBA:ARBA00042893};
GN Name=PER2 {ECO:0000313|Ensembl:ENSOCUP00000000190.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000000190.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000000190.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000000190.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000000190.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; G1SCU7; -.
DR SMR; G1SCU7; -.
DR STRING; 9986.ENSOCUP00000000190; -.
DR PaxDb; 9986-ENSOCUP00000000190; -.
DR Ensembl; ENSOCUT00000000216.4; ENSOCUP00000000190.4; ENSOCUG00000000215.5.
DR eggNOG; KOG3753; Eukaryota.
DR GeneTree; ENSGT00940000156342; -.
DR HOGENOM; CLU_006667_0_0_1; -.
DR InParanoid; G1SCU7; -.
DR TreeFam; TF318445; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000000215; Expressed in skeletal muscle tissue and 17 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0007623; P:circadian rhythm; IEA:UniProt.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR048814; Per1-3_PAS-A.
DR InterPro; IPR022728; Period_circadian-like_C.
DR PANTHER; PTHR11269; PERIOD CIRCADIAN PROTEIN; 1.
DR PANTHER; PTHR11269:SF9; PERIOD CIRCADIAN PROTEIN HOMOLOG 2; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF21353; Per3-like_PAS-A; 1.
DR Pfam; PF12114; Period_C; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 340..383
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 672..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 904..923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1019..1052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..529
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..693
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1028..1045
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1161 AA; 125170 MW; D06D94D4E957A261 CRC64;
MNGYVEFAPS AGHPRVEPLD PRPGKAPVQE DVDMSSGSSG NEANENSSMG RESQGSDCDD
SGKELGMLVE PPDARQGPAA FGLTMAESEP ACVSQQAAKA DVHRELIRTL KELKVHLPAD
RKAKGKASTL ATLKYALRSV KQVKANEEYY QLLMSSESQP RGVDVPSYSV EEVESVTSEY
VVKNGDMFAV AVSLVTGRIL YISEQVASIF HCKRDAFSDA KFVEFLAPHD VSVFHGCTTP
CKLPAWSACS RGDFTQECTE EKSFFCRVSV GKNHENEIRY HPFRMTPYLA KVRERPGAES
QLSCLLLAER VHSGYEAPRI PPEKRIFTTT HTPNCLFQDV DERAVPLLGY LPQDLIESPV
LLQLHPSDRP LMLTIHKKIL QAGGQPFDYS PIRFRARNGE YITLDTSWSS FINPWSRRVS
FIIGRHKVRV GPLNEDVFTA HPCAEEKAPH PGVQELTEQI HRLLLQPVPH SGSSGYGSLG
SNGSQEHLLS HTSSSDSNGH EDSRQRRPEI CKTDKAKARG HHSHGPGEQK KTCVPDLQSG
HAAQERAVPA AEDSSADSAS RAGFPEELAC RPQPACSYQQ ISCLDGVIRY LESCSEAATL
KRKCEFPANI ATRKTTVSPG LHATEAASPP EVNSHAEVSA HLSSLALPSK AESVVSLTSQ
CSYSSTIVHV GDKKPQPELE TVEDAEREPF KPLGLPKEWL PAHTQKKGRS FLTRPRDGGR
LGFPHSPCHH SRQEPPKGRS GERASPGLRN ASGIDSSWKK AGKNRKLKCK RAKPRDSSES
TGSGGPAPPR PPLVGLNATA WSPSATSQSS CPAVPAYSLP VFPAPMAPHA SLTVPTVPLD
AQYQLAVQAP LAPVMALVLP SHPLSLPQAF FPSHAVLQSP AAPASQPEFA RPPCACPATP
ATPPLASGAG GRASPPLFQS RGSSPLQLNL LQLEEAPEGG VGATGTPGTA ATGPDCKPAT
SRDRQLKAPP AQEEPSDTPN SDALSTSSDL LDLLLNDALG SAAGSALVRE QRLGLTGLRR
LPERGSSDTS RSSRYFGSID SSENNHRAAR PPRLGAGEQL LRCVLQDPLW LLMADTDDSV
MMTYQLPARD ADTVLKEDRE QLRLLQKSQP WLTEGQRQEL HEVHPWVQTG GLPAALDVAV
SSQRPLLARA LGTGSAASLG P
//
