ID G1SDD8_RABIT Unreviewed; 147 AA.
AC G1SDD8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Nucleoside diphosphate-linked moiety X motif 6 {ECO:0000256|RuleBase:RU368106};
DE Short=Nudix motif 6 {ECO:0000256|RuleBase:RU368106};
DE EC=3.6.1.- {ECO:0000256|RuleBase:RU368106};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000000419.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000000419.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000000419.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000000419.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000000419.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May contribute to the regulation of cell proliferation.
CC {ECO:0000256|RuleBase:RU368106}.
CC -!- SUBUNIT: Monomer and homodimer. {ECO:0000256|RuleBase:RU368106}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU368106}.
CC Nucleus {ECO:0000256|RuleBase:RU368106}. Mitochondrion
CC {ECO:0000256|RuleBase:RU368106}.
CC -!- SIMILARITY: Belongs to the Nudix hydrolase family.
CC {ECO:0000256|RuleBase:RU003476}.
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DR EMBL; AAGW02053668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SDD8; -.
DR SMR; G1SDD8; -.
DR STRING; 9986.ENSOCUP00000000419; -.
DR PaxDb; 9986-ENSOCUP00000000419; -.
DR Ensembl; ENSOCUT00000000481.4; ENSOCUP00000000419.3; ENSOCUG00000000482.4.
DR eggNOG; KOG0648; Eukaryota.
DR GeneTree; ENSGT00390000008458; -.
DR HOGENOM; CLU_054299_4_0_1; -.
DR InParanoid; G1SDD8; -.
DR TreeFam; TF106346; -.
DR Proteomes; UP000001811; Chromosome 15.
DR Bgee; ENSOCUG00000000482; Expressed in aorta and 16 other cell types or tissues.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 4.10.80.100; -; 1.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR InterPro; IPR020476; Nudix_hydrolase.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR003293; Nudix_hydrolase6-like.
DR InterPro; IPR020084; NUDIX_hydrolase_CS.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR PANTHER; PTHR13994:SF46; NUCLEOSIDE DIPHOSPHATE-LINKED MOIETY X MOTIF 6; 1.
DR PANTHER; PTHR13994; NUDIX HYDROLASE RELATED; 1.
DR Pfam; PF00293; NUDIX; 1.
DR PRINTS; PR01356; GFGPROTEIN.
DR PRINTS; PR00502; NUDIXFAMILY.
DR SUPFAM; SSF55811; Nudix; 1.
DR PROSITE; PS51462; NUDIX; 1.
DR PROSITE; PS00893; NUDIX_BOX; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU368106};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003476};
KW Mitochondrion {ECO:0000256|RuleBase:RU368106};
KW Nucleus {ECO:0000256|RuleBase:RU368106};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 1..104
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS51462"
SQ SEQUENCE 147 AA; 16981 MW; CD8DF9D35FDCD3C8 CRC64;
MWKFPGGLSE PGEDIGDTAV REVFEETGIE SEFQSLLSIR QQHTSPGAFG KSDMYIVCRL
KPFSFTINFC QHECLRCEWM DLTELVKTEN TTPITRRVAG LLLYGYREGF DKIDLTMEKL
PAVYTGLFYK LYHKELPENY KTMIGMD
//
