ID G1SE93_RABIT Unreviewed; 862 AA.
AC G1SE93;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Integrator complex subunit 6 {ECO:0000313|Ensembl:ENSOCUP00000000759.3};
GN Name=INTS6 {ECO:0000313|Ensembl:ENSOCUP00000000759.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000000759.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000000759.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000000759.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000000759.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1SE93; -.
DR SMR; G1SE93; -.
DR STRING; 9986.ENSOCUP00000000759; -.
DR PaxDb; 9986-ENSOCUP00000000759; -.
DR Ensembl; ENSOCUT00000000876.3; ENSOCUP00000000759.3; ENSOCUG00000000876.4.
DR eggNOG; KOG3768; Eukaryota.
DR GeneTree; ENSGT00390000016655; -.
DR HOGENOM; CLU_006789_0_0_1; -.
DR InParanoid; G1SE93; -.
DR TreeFam; TF323386; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000000876; Expressed in testis and 15 other cell types or tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0032039; C:integrator complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0016180; P:snRNA processing; IEA:Ensembl.
DR InterPro; IPR029307; INT_SG_DDX_CT_C.
DR PANTHER; PTHR12957; DEAD/H BOX POLYPEPTIDE 26/DICE1-RELATED; 1.
DR PANTHER; PTHR12957:SF23; INTEGRATOR COMPLEX SUBUNIT 6; 1.
DR Pfam; PF15300; INT_SG_DDX_CT_C; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 783..844
FT /note="INTS6/SAGE1/DDX26B/CT45 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF15300"
FT REGION 701..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 862 AA; 97572 MW; B6C4CFAE4D14192D CRC64;
MSTQSEAATW CTSDCNGWPC AFSVTGRKKK FSRFSFQAGW KENHATFMNE LKNLQAEGLT
TLGQSLRTAF DLLNLNRLVT GIDNYGQGRN PFFLEPAIII TITDGSKLTT TSGVQEELHL
PLNSPLPGSE LTKEPFRWDQ RLFALVLRLP GTMSVESEQL TGVPLDDSAI TPMCEVTGGR
SYSVCSPRML NQCLESLVQK VQSGVVINFE KAGPDPSPVE DGQPDISRPF GSQPWHSCHK
LIYVRPNPKT GVPIGHWPVP ESFWPDQNSP TLPPRTSHPV VKFSCTDCEP MVIDKLPFDK
YELEPSPLTQ FILERKSPQT CWQVYVSNSA KYSELGHPFG YLKASTALNC VNLFVMPYNY
PVLLPLLDDL FKVHKAKPTL KWRQSFENYL KTMPPYYLGP LKKAVRMMGA PNLIADSMEY
GLSYSVISYL KKLSQQAKIE SDRVIGSVGK KVVQETGIKV RSRSHGLSMA YRKDFQQLLQ
GISEDVPHRL LDLNMKEYTG FQVALLNKDL KPQTFRNAYD IPRRNLLDHL TRMRSNLLKS
TRKFLKGQDE DQVHSVPIAQ MGNYQEYLKQ VPSPLRELDP DQPRRLHTFG NPFKLDKKGM
MIDEADEFVA GPQNKHKRPG EPNMQGIPKR RRCMSPLLRG RQQNPVVNNH IGGKGPPVPM
TQAQPDLIKP LPLHKISETT NDSTIDDVIE NHVADQLSSD VTPNAMDTEF STSSSPANLL
ERPTNHTEAL GHDHLGTNDL SVGGFLENHE EPRDKEQCAE ENIPASSLNK GKKLMHCRSH
EEVNTELKAQ IMKEIRKPGR KYERIFTLLK HVQGSLQTRL IFLQNVIKEA SRFKKRMLIE
QLENFLDEIH RRANQINHIN SN
//
