ID G1SEC8_RABIT Unreviewed; 745 AA.
AC G1SEC8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Mitofusin 1 {ECO:0000313|Ensembl:ENSOCUP00000000802.3};
GN Name=MFN1 {ECO:0000313|Ensembl:ENSOCUP00000000802.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000000802.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000000802.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000000802.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000000802.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000000802.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004374}.
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DR EMBL; AAGW02014205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SEC8; -.
DR Ensembl; ENSOCUT00000000929.3; ENSOCUP00000000802.3; ENSOCUG00000000928.3.
DR eggNOG; KOG0448; Eukaryota.
DR GeneTree; ENSGT00390000013727; -.
DR HOGENOM; CLU_021212_1_0_1; -.
DR TreeFam; TF314289; -.
DR Proteomes; UP000001811; Chromosome 14.
DR Bgee; ENSOCUG00000000928; Expressed in heart and 15 other cell types or tissues.
DR ExpressionAtlas; G1SEC8; baseline.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0008053; P:mitochondrial fusion; IEA:InterPro.
DR CDD; cd09912; DLP_2; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR006884; Fzo/mitofusin_HR2.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR027094; Mitofusin_fam.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10465:SF2; MITOFUSIN-1; 1.
DR PANTHER; PTHR10465; TRANSMEMBRANE GTPASE FZO1; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF04799; Fzo_mitofusin; 1.
DR SUPFAM; SSF111479; Fzo-like conserved region; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 75..324
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT COILED 684..742
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 745 AA; 84469 MW; AAC27EE8AF1C9B8C CRC64;
MSIMAETASP LKHFVLAKKA ITTIFDQLLE FVTEGSRFVE ATYKNPELDR IAAEDDLVEI
QSYKNKLSII GEVLSRRHMK VAFFGRTSSG KSSVINAMLW DKVLPSGIGH TTNCFLSVEG
TDGDKAYLMT EGSDEKKSVK TVNQLAHALH MDKDLKAGCL VHVFWPKAKC ALLRDDLVLV
DSPGTDVTTE LDSWIDKFCL DADVFVLVAN SESTLMNTEK HFFHKVNERL SKPNIFILNN
RWDASASEPE YMEDVRRQHM ERCLHFLVEE LKVVDPLEAQ NRIFFVSAKE VLSARKHKTQ
GMPEGGGALA EGFQARLQEF QNFEQIFEEC ISQSAVKTKF EQHTIRAKQI LDTVKNILDS
INVAAAEKRV YSMEEREDQI DRLDFIRNQM NLLTLDVKKK IKEVTEEVAN KVSCAMTDEI
CRLSVLVDEF CSEFHPTPSV LKVYKSELNK HIEDGMGRNL ADRCTNEVNA SMLQSQQEII
ENLKPLLPAG IQSKLHTLIP CKKFDLSYDL NCHKLCSDFQ EDIVFRFSLG WASLVHRFLG
PTNAQRVLLG LSEPIFQLPR SLASTPTAPA NPGMPDNASQ EELMVTLITG LASLTSRTSM
GIIVVGGVIW KTIGWKLVSI SLSMYGALYL YERLTWTTRA KERAFKQQFV NYATEKLQMI
VSFTSANCSH QVQQEMATTF ARLCQQVDIT QRHLEEEIAR LSKEIDQLEK IQNNSKLLRN
KAVQLENELE NFTKQFLHSS NEEKS
//
