ID G1SEG0_RABIT Unreviewed; 1346 AA.
AC G1SEG0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Zinc finger protein 541 {ECO:0000313|Ensembl:ENSOCUP00000000838.3};
GN Name=ZNF541 {ECO:0000313|Ensembl:ENSOCUP00000000838.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000000838.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000000838.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000000838.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000000838.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008249042.1; XM_008250820.2.
DR STRING; 9986.ENSOCUP00000000838; -.
DR PaxDb; 9986-ENSOCUP00000000838; -.
DR Ensembl; ENSOCUT00000000969.3; ENSOCUP00000000838.3; ENSOCUG00000000969.3.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; KOG4167; Eukaryota.
DR GeneTree; ENSGT00940000160330; -.
DR HOGENOM; CLU_006052_0_0_1; -.
DR InParanoid; G1SEG0; -.
DR OMA; FAYDCPD; -.
DR OrthoDB; 2906194at2759; -.
DR TreeFam; TF106431; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000000969; Expressed in testis.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR000949; ELM2_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR16089; REST COREPRESSOR COREST PROTEIN-RELATED; 1.
DR PANTHER; PTHR16089:SF23; ZINC FINGER PROTEIN 541; 1.
DR Pfam; PF01448; ELM2; 1.
DR Pfam; PF00096; zf-C2H2; 1.
DR Pfam; PF13912; zf-C2H2_6; 2.
DR SMART; SM01189; ELM2; 1.
DR SMART; SM00717; SANT; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51156; ELM2; 1.
DR PROSITE; PS51293; SANT; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 141..168
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 169..196
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 823..850
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1046..1138
FT /note="ELM2"
FT /evidence="ECO:0000259|PROSITE:PS51156"
FT DOMAIN 1153..1204
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 1284..1311
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 672..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 865..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 914..961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1215..1281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..124
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..600
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..932
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1215..1255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1346 AA; 144823 MW; 1631B927D64DDEAA CRC64;
MEQCGLGDEG TLPSGVHLPS FPESQGLGCS DALNRDLGPD TRDLLYAGLS GLELEPSLPT
PDVPSEALED NLDALSLYSG KDSDSVKLLE EYADPESQTA LHDLGLGVLK VPKEPEDGGR
AASGSARKGK RQHSSPQNPL LDCSLCGKLF SSASSLSKHY LTHSQERKHV CKICSKAFKR
QDHLTGHMLT HQKTKPFVCI EQGCSKSYCD YRSLRRHYEV QHGLCILKEA PPEEEACGDA
PHPHELAPSG LRSLGPPEAR SPSALLPNRD LLRCIVSSIV HQKIPSPGPA LAGPADSEGR
NSACPCPTSS ASSCTPASAP AALGALGTEG PEEPRASHKE AATHSRAAEN GAPDPLESEP
PVPPLPSTLE GWPEGGALPA CLPLFRSQTV PAGSQPSGHN FQWLRNLPGC PKSKGNNLFV
VHKPPAVPSR EGCESGPGPS SASPSAEPLS SASTGPGPED VPAFPPTLLK GPAEAPGDPR
YAGGEDDAWA SKKSKFDCDS FSWQSPGEPG AQDVQKTGGL PSDATPLFRQ LFLKSQESLV
SHEQMQVLQM ITKSQRIFSH AQVAAAATSQ LPGPEGKQAT LKPWPQQPPP PAPPMDSLHA
GPGNPEPEGS PARRRKPVPA GPREASPGSS RRDAKGGPKV AAAPSALTAP ALDPCGKPDI
SSLAKQLRSS KGTLDLGGIP PAVGSRQIQP AGDELPGQQA VAENSTAPGA AKGEKGPGSS
RGGGYRLFSG HPRAQRFPGF RREKMKMDMC CAASPSQVAM ASFSAGPPAD PPRDAKSKLT
VLNRIQGGNV YRIPHPSRDE HAAGTCSHQN GGPGEWTEPR STYVCKNCSQ MFYTEKGLNS
HMCFHSDQWP SPRGKQEQQV FGTEFCKPPR QALRPDGDGQ TPLRAKKPLD STAVASVVIP
MPVPVALGSR ALGSLAKGQE KDEEERDGKE GSQHRKRKKR PQSKALLIPP PPSAFRVPSP
GGHQSCLRSP VFLVDRLLQG LFQCSPYTPP PMLSPIREGS GLYFNTLCST CPQAGTSQLS
SSMLDQGDSS FGICVVKDDS KISIEPHINI GSRFQADIPE LQDRSLAGID EHVASLVWKP
WGDVMTNPET QDRVTELCNV ACSSVMPGGG TNLELALHCL HEAQGSVQVA LETLLLRGPQ
KPRTHPLADY RYTGSDIWTP IEKRLFKKAF CAHKKDFYLI HKTIQTKTVA QCVEYYYIWK
KMLKFDCGRV PGLEKRTKRE PEEAERPEEK ATGSPRETPS HRPTPDFKMK TKSFRRESIL
NSSPNAGPRR TPEAPGSVES QGVFPCRECE RVFDKIKSRN AHMKRHRLQD HVEPVVRVKW
PVKPFQLKEE EEEEEELGAA IGPLQW
//
