ID G1SEI4_RABIT Unreviewed; 289 AA.
AC G1SEI4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=N-myc and STAT interactor {ECO:0000313|Ensembl:ENSOCUP00000000865.4};
GN Name=NMI {ECO:0000313|Ensembl:ENSOCUP00000000865.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000000865.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000000865.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000000865.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000000865.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000000865.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the NMI family. {ECO:0000256|ARBA:ARBA00010081}.
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DR EMBL; AAGW02004644; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02004645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SEI4; -.
DR Ensembl; ENSOCUT00000001001.4; ENSOCUP00000000865.4; ENSOCUG00000001001.4.
DR eggNOG; ENOG502QVH1; Eukaryota.
DR GeneTree; ENSGT00530000063686; -.
DR HOGENOM; CLU_047262_0_0_1; -.
DR TreeFam; TF332752; -.
DR Proteomes; UP000001811; Chromosome 7.
DR Bgee; ENSOCUG00000001001; Expressed in aorta and 16 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR CDD; cd12544; RRM_NMI; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR009909; Nmi/IFP35_dom.
DR InterPro; IPR009938; Nmi/IFP35_N.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR PANTHER; PTHR15225; INTERFERON-INDUCED PROTEIN 35/NMI N-MYC/STAT INTERACTING PROTEIN; 1.
DR PANTHER; PTHR15225:SF4; N-MYC-INTERACTOR; 1.
DR Pfam; PF07334; IFP_35_N; 1.
DR Pfam; PF07292; NID; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 28..103
FT /note="Nmi/IFP 35"
FT /evidence="ECO:0000259|Pfam:PF07334"
FT DOMAIN 104..192
FT /note="NID"
FT /evidence="ECO:0000259|Pfam:PF07292"
FT DOMAIN 202..255
FT /note="NID"
FT /evidence="ECO:0000259|Pfam:PF07292"
FT COILED 8..49
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 289 AA; 32807 MW; 72DC9F7F52D7AE1E CRC64;
MAAGEDNKQQ VLKEYADATL ENAEIERLID DIAKENALLK EEIQKFEAEL QENPGDFQIK
EDIPGTKMKF VSVENPVNDN QFLNVSCSFQ VNLEVPYELQ KGQALVTFEQ EEVAQNVIRM
GNHCVQIQDI NMKVKAKPVP LNSGVRFQVC AEISKVKINV NGIPDELPED QMRDKLELSF
CKTRNGGGEV ESVKYDKRTG SAVITFVETG VADRILERKD YPLYTNLKCH RVMVSPYMET
HLKKYQAFSG VSKRTDFIGI HFQREKNGGG EVEVVKCALQ QPYTAYFEE
//
