ID G1SF84_RABIT Unreviewed; 1028 AA.
AC G1SF84;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=IQ motif and Sec7 domain ArfGEF 1 {ECO:0000313|Ensembl:ENSOCUP00000001155.3};
GN Name=IQSEC1 {ECO:0000313|Ensembl:ENSOCUP00000001155.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000001155.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000001155.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000001155.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000001155.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000001155.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BRAG family.
CC {ECO:0000256|ARBA:ARBA00006248}.
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DR EMBL; AAGW02056194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02056195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02056196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02056197; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02056198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02056199; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02056200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02056201; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SF84; -.
DR PaxDb; 9986-ENSOCUP00000001155; -.
DR Ensembl; ENSOCUT00000001342.4; ENSOCUP00000001155.3; ENSOCUG00000001343.4.
DR eggNOG; KOG0931; Eukaryota.
DR GeneTree; ENSGT00940000156915; -.
DR HOGENOM; CLU_004328_0_1_1; -.
DR OMA; AGHSAHH; -.
DR TreeFam; TF323811; -.
DR Proteomes; UP000001811; Chromosome 9.
DR Bgee; ENSOCUG00000001343; Expressed in frontal cortex and 16 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13318; PH_IQSEC; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR033742; IQSEC_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF327; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF16453; IQ_SEC7_PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 517..710
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 21..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 350..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 872..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 916..979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..443
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 884..898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..959
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1028 AA; 115329 MW; 342B9DE2B3CF117B CRC64;
MWCLHCNSER TQSLLELELD SGVEGEAPSS ETGTSLDSPS AYHQGPLLPG SSLSPDHYEH
TSVGAYGLYS GPPGQQQRTR RPKLQHSTSI LRKQAEEEAI KRSRSLSESY ELSSDLQDKQ
VEMLERKYGG RLVTRHAART IQTAFRQYQM NKNFERLRSS MSENRMSRRI VLSNMRMQFS
FEGPEKVHSS YFEGKQVSVT NDGSQLGALV PPECGDLGEP STLKSPAPSS DFADAITELE
DAFSRQVKSL AESIDDALNC RSLHTEEAPV PEVVRARDSE PKPPLHSMDH HKLDEMTASY
SDVTLYIDEE ELSPPLPISQ VGDRPSSTES DLRLRAGGMA QDYWALAHKD DKVDTDTSCR
STPSLERQEQ RLRVEHLPLL TIEPPSDSSV DLSDRSERGS LKRQSAYERS LAGQQGSPKH
GPHSGPPKVL SREEPDLRPR PPRPLDSHLA INGSANRQSK SESDYSDGDN DSINSTSNSN
DTINCSSESS SRDSLREQTL SKQTYHKETR NSWDSPAFSN DVIRKRHYRI GLNLFNKKPE
KGVQYLIERG FVPDTPVGVA HFLLQRKGLS RQMIGEFLGN RQKQFNRDVL DCVVDEMDFS
AMELDEALRK FQAHIRVQGE AQKVERLIEA FSQRYCICNP GVVRQFRNPD TIFILAFAII
LLNTDMYSPN VKPERKMKLE DFVKNLRGVD DGEDIPREML IGIYERIRKR ELKTNEDHVS
QVQKVEKLIV GKKPIGSLHH GLGCVLSLPH RRLVCYCRLF EVPDPNKPQK LGLHQREIFL
FNDLLVVTKI FQKKKNSVTY SFRQSFSLYG MQVLLFENQY YPNGIRLTSA VPGADIKVLI
NFNAPNPQDR KKFTDDLRES IAEVQEMEKH RIESELEKQK GVVRPSMSQC SSLKKESGNG
TLGRACLDDS YTSGEGLKRS ALSSSLRDLS EAGKRGRRSS AGSLESNVEG SIISSPHMRR
RATSTRECPS RPHQPMPHSS SLLGSLFGIS AFRASAATSA VLLSVGPEDC LTAPARAERP
FRKGEATA
//