ID G1SG74_RABIT Unreviewed; 821 AA.
AC G1SG74;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Family with sequence similarity 171 member B {ECO:0000313|Ensembl:ENSOCUP00000001569.2};
GN Name=FAM171B {ECO:0000313|Ensembl:ENSOCUP00000001569.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000001569.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000001569.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000001569.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000001569.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000001569.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the FAM171 family.
CC {ECO:0000256|ARBA:ARBA00006818}.
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DR EMBL; AAGW02003598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02003599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002712377.1; XM_002712331.3.
DR AlphaFoldDB; G1SG74; -.
DR STRING; 9986.ENSOCUP00000001569; -.
DR PaxDb; 9986-ENSOCUP00000001569; -.
DR Ensembl; ENSOCUT00000001825.4; ENSOCUP00000001569.2; ENSOCUG00000001825.4.
DR GeneID; 100339725; -.
DR KEGG; ocu:100339725; -.
DR CTD; 165215; -.
DR eggNOG; ENOG502QRHY; Eukaryota.
DR GeneTree; ENSGT00950000183184; -.
DR HOGENOM; CLU_019729_0_1_1; -.
DR InParanoid; G1SG74; -.
DR OMA; WIAAPHP; -.
DR OrthoDB; 4260817at2759; -.
DR TreeFam; TF331338; -.
DR Proteomes; UP000001811; Chromosome 7.
DR Bgee; ENSOCUG00000001825; Expressed in frontal cortex and 15 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR018890; FAM171.
DR InterPro; IPR049175; FAM171_C.
DR InterPro; IPR048530; FAM171_N.
DR PANTHER; PTHR31626:SF2; PROTEIN FAM171B; 1.
DR PANTHER; PTHR31626; SUSHI DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF20771; FAM171A1-2-B_C; 1.
DR Pfam; PF10577; FAM171A1-2-B_N; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..821
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003422547"
FT TRANSMEM 349..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 79..326
FT /note="FAM171 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10577"
FT DOMAIN 573..819
FT /note="FAM171 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF20771"
FT REGION 45..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 772..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..821
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 821 AA; 91155 MW; 655DCB32977C842C CRC64;
MARLCRRVPC TLLLGLAAVL LKARLVPAAA RAELSRSDLS LIQQQQQQQQ QRQREEAEEE
RPGVPGAAST LTVPVSMFML KVQVNDIISR QYLSQAVVEV FVNYTKTNST VTKNNGAVLI
KVPYKLGLSL TIIAYKDGYV LTSLPWKTGR MPIYSSVTLS LFPQSQANIW LFEDTVLITG
KLADAKSQPS VQFSKALIKL PDNHHISNVT GYLTVLQQFL KVDNFLYSTG ITLSKPGFEN
IELTPLAAIC VKIYSGGKEL KVDGPIQISL PLLHTNDISV GDRIPAWTLD MNTGAWVNHG
RGMVKEHNNH LVWTYDAPHL GYWIAAPLPG SRGSGANEDS KDITAYHTVF LTAILGGTIV
IVIGFFVVLL CYCRGKCGTP QKRERNITKL EVLKRDQTTS TTHINHISSV KVALKAEEKS
QLFNAKNSTH SPQKKEPANA EPEERVSMVK TRDNFKIYNE DVAFLSVNQN TYSRNATQSL
EPNVGSRQPN HINNNVSSSL GDAQEEKRYL TGNEGVFGHS HIPEQLMHIY SQPIAILQTS
DLFSTPEQLH AAKSATLPRK GQLVYGQLME PVNRENFTQT LPKMPMHSHA QPPEAREEDM
VLEGQQSLPS QTSDWSRYSS SLLESVSVPG TLNEAVVMTP FSSELQGISE QTLLELSKGK
PSPHPRAWFV SLDGKPVAQV RHSFIDLKKG KRAQSNDTSL DSGVDMNELH SSRKLEREKT
FIKSMHQPKI LYLEDLDLSS SESGTTVCSP EDPALRHILD GGSGVIMEHP GEESLGRKST
VEDFEANTSP TRKRGRPPLA KRDSKTNIWK KREERPLIPI N
//
