ID G1SGV4_RABIT Unreviewed; 256 AA.
AC G1SGV4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=tRNA-splicing endonuclease subunit Sen15 domain-containing protein {ECO:0000259|Pfam:PF09631};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000001833.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000001833.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000001833.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000001833.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SEN15 family.
CC {ECO:0000256|ARBA:ARBA00006091}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G1SGV4; -.
DR SMR; G1SGV4; -.
DR STRING; 9986.ENSOCUP00000001833; -.
DR Ensembl; ENSOCUT00000002125.4; ENSOCUP00000001833.4; ENSOCUG00000002126.4.
DR eggNOG; ENOG502S21U; Eukaryota.
DR GeneTree; ENSGT00390000014781; -.
DR HOGENOM; CLU_130469_1_0_1; -.
DR InParanoid; G1SGV4; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000002126; Expressed in autopod skin and 17 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IEA:InterPro.
DR Gene3D; 3.40.1350.10; -; 1.
DR InterPro; IPR018593; tRNA-endonuc_su_Sen15.
DR InterPro; IPR011856; tRNA_endonuc-like_dom_sf.
DR InterPro; IPR036167; tRNA_intron_Endo_cat-like_sf.
DR PANTHER; PTHR28582; TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15; 1.
DR PANTHER; PTHR28582:SF1; TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15; 1.
DR Pfam; PF09631; Sen15; 1.
DR SUPFAM; SSF53032; tRNA-intron endonuclease catalytic domain-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 66..165
FT /note="tRNA-splicing endonuclease subunit Sen15"
FT /evidence="ECO:0000259|Pfam:PF09631"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 256 AA; 27417 MW; 8D02440A4B7173EC CRC64;
VERGGRAAPA GTTPLPSGSQ PLGAPSRGGS GPLAWPRLRL HGSPDLHLCM MELDAGDATQ
VYAAFLVFLD LMESKSWHEV NCVGLPELQL ICLVGTEIEG EGLQTIVPTP VTASLSHNRI
REILQASRKL RGDPDLPMSF TLAIVESDST IVYYRLTDGF TLPDPQVSGE VTDSGSEEGQ
PLRDAPLPLP PGNAGEGVVL ASEDWLWLWL CSVRSGVFPL TAARWFPCSG ECPRVPDVSR
GRWAAELGPS SLGERL
//
