ID G1SGY3_RABIT Unreviewed; 1056 AA.
AC G1SGY3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Neogenin 1 {ECO:0000313|Ensembl:ENSOCUP00000001864.3};
GN Name=NEO1 {ECO:0000313|Ensembl:ENSOCUP00000001864.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000001864.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000001864.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000001864.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000001864.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1SGY3; -.
DR Ensembl; ENSOCUT00000002159.3; ENSOCUP00000001864.3; ENSOCUG00000002157.3.
DR eggNOG; KOG4221; Eukaryota.
DR GeneTree; ENSGT00940000156684; -.
DR HOGENOM; CLU_004256_1_0_1; -.
DR TreeFam; TF321506; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000002157; Expressed in aorta and 17 other cell types or tissues.
DR CDD; cd00063; FN3; 5.
DR CDD; cd05722; IgI_1_Neogenin_like; 1.
DR CDD; cd05723; IgI_4_Neogenin_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF14; NEOGENIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF13927; Ig_3; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR01832; VEGFRECEPTOR.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50853; FN3; 5.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 33..128
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 133..220
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 225..312
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 317..402
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 419..513
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 519..609
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 614..709
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 719..809
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 834..930
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 498..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 957..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1056 AA; 116114 MW; A66DE26E81996CE5 CRC64;
YSTCLICVWH FKCRSALCFG FVSVGAGVRT FTPFYFLVEP VDTLSVRGSS VILNCSAYSE
PLPKIEWKKD GTFLNLVSDD RRQLLPDGSL FISNVVHSKH NKPDEGYYQC VATVESLGTI
VSRTAKLTVA GLPRFISQPE PSSAYAGNSA VLNCEVNADL APFVRWEQDR QPLLLDDRVA
KLPSGALVIS NVTEADGGLY RCVVDSGGGP PKFSDEAELK VLADPEVPSD LVFLKQPPSL
VRAVGQSVVL PCVASGLPAP SIRWLKNEEL DSKTSKLYNL LEISEVTQDD AGTYSCVAGS
GNETIEAQAE LTVQAPPEFL KRPASLYAHE SMDIVFECEV TGKPAPTVKW VKNGDVVIPS
DYFKIVKEHN LQVLGLVKSD EGFYQCIAEN DVGNAQAGAQ LVILEEALPS ATTGPLPSAP
RDVVASLVST RFIKLTWRTP ASDPQGDSLT YSVFYTKEGT ARERVENTSR PGEMQVTIQN
LMPATVYIFR VTAQNRHGSG ESSAPLRVET QPEVQLPGPA PNIRAYATSP TSITVTWETP
LSGNGEIQNY KLYYLEKGTD KEQDIDVSSH SYTLNGLKKH TEYTFRVVAY NKHGPGVSTQ
DVTVRTLSDV PSAAPQNLSL EVRNSKSIVV HWQPPPPATQ NGLISGYKIR YRKASRKSDV
TETLVVGTQL SQLIEGLDRG TEYNFRVAAL TINGTGPATD WLSAETFESD LDETRVPEVP
SSLHVRPLVT SIVVSWTPPE NQNIVVRGYA IGYGIGSPHA QTIKVDYKQR YYTIENLDPS
SHYVITLKAF NHVGEGIPLY ESAVTRPHTD TSEVDLFVVN APYTPVPDPT PMMPPVGVQA
SILSHDTVRV TWADNSLPKH QKITDSRYYT VRWKTNIPAN TKYKNANATT LSYLVTGLKP
NTLYEFSVMV TKGRRSSTWS MTAHGTTFEL VPTSPPKDVT VVSKEGKPRT IIVNWQPPSE
ANGKITGKRS LHGHRSGPRD PAWPEHLRRA RCCWERRERK ADSTDLWVVR VGTLVRLEWR
CCWPTVGVNG PTQTTAGCTR HQPLALLGPG AQVYFL
//
