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Database: UniProt
Entry: G1SHL5_RABIT
LinkDB: G1SHL5_RABIT
Original site: G1SHL5_RABIT 
ID   G1SHL5_RABIT            Unreviewed;      2639 AA.
AC   G1SHL5;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   28-MAR-2018, entry version 36.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSOCUP00000002126};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSOCUP00000002126};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000002126, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000002126, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000002126}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000002126};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   EMBL; AAGW02026444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOCUT00000002456; ENSOCUP00000002126; ENSOCUG00000002425.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000001811; Chromosome 16.
DR   Bgee; ENSOCUG00000002425; -.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT   DOMAIN      216    426       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      642    839       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      974   1179       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED       89    109       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2639 AA;  298305 MW;  2DE9132D3B390689 CRC64;
     MGSIQRKAIM HHEGHMDDGL NLSRSQHEES RTARVIRSTV FLFNRFIRGL DALSKKAKAS
     SVDLPIESVS LSLQDLIGYF HPPDEHLEHE DKQNRLRALK NRQNLFQEEG MINLVLECID
     RLHVYSSAAH FADVAGREAG ESWKSILNSL YELLAALIRG NRKNCAQFSG SLDWLISRLE
     RLEASSGILE VLHCVLVESP EALNIIKEGH IKSIISLLDK HGRNHKVLDV LCSLCVCHGV
     AVRSNQHLIC DNLLPGRDLL LQTRLVNHVS SMRPNIFLGV SEGSAQYKKW YYELMVDHTE
     PFVTAEATHL RVGWASTEGY SPYPGGGEEW GGNGVGDDLF SYGFDGLHLW SGCIARTVSS
     PNQHLLRTDD VISCCLDLSA PSISFRINGQ PVQGMFENFN IDGLFFPVVS FSAGIKVRFL
     LGGRHGEFKF LPPPGYAPCY EAVLPKEKLK VEHSREYKQE RTYTRDLLGP TVSLTQAAFT
     PIPVDTSQIV LPPHLERIRE KLAENIHELW VMNKIELGWQ YGPVRDDNKR QHPCLVEFSK
     LPEQERNYNL QMSLETLKTL LALGCHVGIS DEHAEEKVKK MKLPKNYQLT SGYKPAPMDL
     SFIKLTPSQE AMVDKLAENA HNVWARDRIR QGWTYGIQQD VKNRRNPRLV PYTLLDDRTK
     KSNKDSLREA VRTLLGYGYN LEAPDQDHAA RAEVCSGTGE RFRIFRAEKT YAVKAGRWYF
     EFEAVTSGDM RVGWSRPGCQ PDQELGSDER AFAFDGFKAQ RWHQGNEHYG RSWQAGDVVG
     CMVDMNEHTM MFTLNGEILL DDSGSELAFK DFDVGDGFIP VCSLGVAQVG RMNFGKDVST
     LKYFTICGLQ EGYEPFAVNT NRDITMWLSK RLPQFLQVPS NHEHIEVTRI DGTIDSSPCL
     KVTQKSFGSQ NSNTDIMFYR LSMPIECAEV FSKTVPGGLP GAGLFGPKND LEDYDADSDF
     EVLMKTAHGH LVPDRVDKDK ETTKAEFNNH KDYAQEKPSR LKQRFLLRRT KPDYSTSHSA
     RLTEDVLADD RDDYDFLMQT STYYYSVRIF PGQEPANVWV GWITSDFHQY DTGFDLDRVR
     TVTVTLGDEK GKVHESIKRS NCYMVCAGES MSPGQGRNNN GLEIGCVVDA ASGLLTFIAN
     GKELSTYYQV EPSTKLFPAV FAQATSPNVF QFELGRIKNV MPLSAGLFKS EHKNPVPQCP
     PRLHVQFLSH VLWSRMPNQF LKVDVSRISE RQGWLVQCLD PLQFMSLHIP EENRSVDILE
     LTEQEELLKF HYHTLRLYSA VCALGNHRVA HALCSHVDEP QLLYAIENKY MPGLLRTGYY
     DLLIDIHLSS YATARLMMNN EFIVPMTEET KSITLFPDEN KKHGLPGIGL STSLRPRMQF
     SSPSFVSINN ECYQYSPEFP LDILKAKTIQ MLTEAVKEGS LHARDPVGGT TEFLFVPLIK
     LFYTLLIMGI FHNEDLRHIL QLIEPSVFKD AATPEEEGDT LEEEPSVEDT KLEGAGEEEA
     KVGKRPKEGL LQMKLPEPVK LQMCLLLQYL CDCQVRHRIE AIVAFSDDFV AKLQDNQRFR
     YNEVMQALNM SAALTARKTK EFRSPPQEQI NMLLNFKDDK SECPCPEEIR DQLLDFHEDL
     MTHCGIELDE DGSLDGNSDL TIRGRLLSLV EKVTYLKKKQ TEKPVESDSR KSSTLQQLIS
     ETMVRWAQES VIEDPELVRA MFVLLHRQYD GIGGLVRALP KTYTINGVSV EDTINLLASL
     GQIRSLLSVR MGKEEEKLMI RGLGDIMNNK VFYQHPNLMR ALGMHETVME VMVNVLGGGE
     SKEITFPKMV ANCCRFLCYF CRISRQNQKA MFDHLSYLLE NSSVGLASPA MRGSTPLDVA
     AASVMDNNEL ALALREPDLE KVVRYLAGCG LQSCQMLVSK GYPDIGWNPV EGERYLDFLR
     FAVFCNGESV EENANVVVRL LIRRPECFGP ALRGEGGNGL LAAMEEAIKI AEDPSRDGPS
     PTSGSSKTLD TEEEEDDTIH MGNAIMTFYA ALIDLLGRCA PEMHLIHAGK GEAIRIRSIL
     RSLIPLGDLV GVISIAFQMP TIAKDGNVVE PDMSAGFCPD HKAAMVLFLD RVYGIEVQDF
     LLHLLEVGFL PDLRAAASLD TAALSATDMA LALNRYLCTA VLPLLTRCAP LFAGTEHHAS
     LIDSLLHTVY RLSKGCSLTK AQRDSIEVCL LSICGQLRPS MMQHLLRRLV FDVPLLNEHA
     KMPLKLLTNH YERCWKYYCL PGGWGNFGAA SEEELHLSRK LFWGIFDALS QKKYEQELFK
     LALPCLSAVA GALPPDYMES NYVSMMEKQS SMDSEGNFNP QPVDTSNIII PEKLEYFINK
     YAEHSHDKWS MDKLANGWIY GEIYSDSSKI QPLMKPYKLL SEKEKEIYRW PIKESLKTML
     AWGWRIERTR EGDSMALYNR TRRISQTSQV SVDAAHGYSP RAIDMSNVTL SRDLHAMAEM
     MAENYHNIWA KKKKLELESK GGGNHPLLVP YDTLTAKEKA KDREKAQDIL KFLQINGYAV
     SRGFKDLELD TPSIEKRFAY SFLQQLIRYV DEAHQYILEF DGGSRSKGEH FPYEQEIKFF
     AKVVLPLIDQ YFKNHRLYFL SAASRPLCSG GHASNKEKEM VTSLFCKLGV LVRHRISLF
//
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