ID G1SHZ4_RABIT Unreviewed; 374 AA.
AC G1SHZ4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Keratin, type II cytoskeletal 7 {ECO:0000256|ARBA:ARBA00039431};
DE AltName: Full=Cytokeratin-7 {ECO:0000256|ARBA:ARBA00042963};
DE AltName: Full=Keratin-7 {ECO:0000256|ARBA:ARBA00042887};
DE AltName: Full=Type-II keratin Kb7 {ECO:0000256|ARBA:ARBA00043134};
GN Name=KRT7 {ECO:0000313|Ensembl:ENSOCUP00000002279.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000002279.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000002279.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000002279.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000002279.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000002279.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit
CC EIF3S10. Interacts with GPER1. {ECO:0000256|ARBA:ARBA00038822}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAGW02059013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02059014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SHZ4; -.
DR SMR; G1SHZ4; -.
DR STRING; 9986.ENSOCUP00000002279; -.
DR PaxDb; 9986-ENSOCUP00000002279; -.
DR Ensembl; ENSOCUT00000002638.4; ENSOCUP00000002279.4; ENSOCUG00000002632.4.
DR eggNOG; ENOG502QURK; Eukaryota.
DR GeneTree; ENSGT00940000161303; -.
DR HOGENOM; CLU_012560_5_1_1; -.
DR InParanoid; G1SHZ4; -.
DR TreeFam; TF317854; -.
DR Proteomes; UP000001811; Chromosome 4.
DR Bgee; ENSOCUG00000002632; Expressed in upper lobe of left lung and 11 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF21; KERATIN, TYPE II CYTOSKELETAL 7; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR SUPFAM; SSF46579; Prefoldin; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 10..321
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 14..112
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 219..299
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 374 AA; 41660 MW; D8DE359348C98B05 CRC64;
MCGGQVRREE HEQIKTLNNK FASFIDKVRF LEQQNQLLET KWALLQEQGS PKSSRLPSIL
EAQVAGLRGQ LEALQVDGGR LEAELRDMQD AVEDFKNKYE DEINHRTAAE NEFVVLKKDV
TRLHEQGGAG DQGGALNDEI NFLRALNEQE IRELQSQISD MSVVLSMDNN RSLDLDSIIA
EVRAQYEDIA QRSKAEAESV YQTKVETLQA QAGKHGDDLR STRNEISEMS RAVQRLQAEL
DGVKNQRARL EAAIADAEQR GELALQDARA KQAELEEALQ RAKQDMARQL REYQELMNVK
LALDIEIATY RKLLEGEESR CGAGGPYSLS DLMEVTPGGP SKWDLSQGTM GSNALSFSSA
GGPGTLKALR SIRS
//
