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Database: UniProt
Entry: G1SI46_RABIT
LinkDB: G1SI46_RABIT
Original site: G1SI46_RABIT 
ID   G1SI46_RABIT            Unreviewed;       804 AA.
AC   G1SI46;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   08-MAY-2019, entry version 63.
DE   RecName: Full=Metalloendopeptidase {ECO:0000256|RuleBase:RU361183};
DE            EC=3.4.24.- {ECO:0000256|RuleBase:RU361183};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000002340, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811};
RG   The Genome Sequencing Platform;
RG   The Genome Assembly Team;
RA   Lindblad-Toh K., Chang J.L., Gnerre S., Clamp M., Lander E.S.;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811};
RG   The Genome Sequencing Platform;
RG   The Assembly Computation and Development Core Team;
RA   Di Palma F., Heiman D., Young S., Gnerre S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "Version 2 of The Genome Sequence of Oryctolagus cuniculus (European
RT   rabbit).";
RL   Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSOCUP00000002340}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000002340};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [4] {ECO:0000313|Ensembl:ENSOCUP00000002340}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000002340};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRSR:PIRSR001199-2,
CC         ECO:0000256|RuleBase:RU361183};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR001199-
CC       2, ECO:0000256|RuleBase:RU361183};
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR   STRING; 9986.ENSOCUP00000002340; -.
DR   Ensembl; ENSOCUT00000002702; ENSOCUP00000002340; ENSOCUG00000002698.
DR   eggNOG; KOG3714; Eukaryota.
DR   eggNOG; ENOG410ZPX7; LUCA.
DR   GeneTree; ENSGT00940000157225; -.
DR   InParanoid; G1SI46; -.
DR   OMA; GHFCGYD; -.
DR   TreeFam; TF314351; -.
DR   Proteomes; UP000001811; Unplaced.
DR   Bgee; ENSOCUG00000002698; Expressed in 3 organ(s), highest expression level in prefrontal cortex.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00041; CUB; 5.
DR   Gene3D; 2.60.120.290; -; 5.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR015446; BMP_1/tolloid-like.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001506; Peptidase_M12A.
DR   InterPro; IPR006026; Peptidase_Metallo.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   Pfam; PF01400; Astacin; 1.
DR   Pfam; PF00431; CUB; 5.
DR   Pfam; PF07645; EGF_CA; 1.
DR   PIRSF; PIRSF001199; BMP_1/tolloid-like; 1.
DR   PRINTS; PR00480; ASTACIN.
DR   SMART; SM00042; CUB; 5.
DR   SMART; SM00181; EGF; 2.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00235; ZnMc; 1.
DR   SUPFAM; SSF49854; SSF49854; 5.
DR   PROSITE; PS00010; ASX_HYDROXYL; 2.
DR   PROSITE; PS01180; CUB; 5.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01187; EGF_CA; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00438935};
KW   Hydrolase {ECO:0000256|RuleBase:RU361183,
KW   ECO:0000256|SAAS:SAAS00973787};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR001199-2,
KW   ECO:0000256|RuleBase:RU361183, ECO:0000256|SAAS:SAAS00973795};
KW   Metalloprotease {ECO:0000256|RuleBase:RU361183,
KW   ECO:0000256|SAAS:SAAS01068076};
KW   Protease {ECO:0000256|RuleBase:RU361183,
KW   ECO:0000256|SAAS:SAAS00973825};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Repeat {ECO:0000256|SAAS:SAAS00792548};
KW   Zinc {ECO:0000256|PIRSR:PIRSR001199-2, ECO:0000256|RuleBase:RU361183,
KW   ECO:0000256|SAAS:SAAS00973802}.
FT   DOMAIN      134    252       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      253    365       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      365    406       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      409    521       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      521    561       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      565    677       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      678    794       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   ACT_SITE     30     30       {ECO:0000256|PIRSR:PIRSR001199-1}.
FT   METAL        29     29       Zinc; catalytic. {ECO:0000256|PIRSR:
FT                                PIRSR001199-2}.
FT   METAL        33     33       Zinc; catalytic. {ECO:0000256|PIRSR:
FT                                PIRSR001199-2}.
FT   METAL        39     39       Zinc; catalytic. {ECO:0000256|PIRSR:
FT                                PIRSR001199-2}.
SQ   SEQUENCE   804 AA;  91934 MW;  D9F2FD0CE9DF048D CRC64;
     CCSYVGRRGN GPQAISIGKN CDKFGIVVHE LGHVIGFWHE HTRPDRDNHV TIIRENIQPG
     QEYNFLKMEP GEVNSLGERY DFDSIMHYAR NTFSRLDSQI YTFEVIGYYL HPSHSSLTTV
     YEGRLRKERK RQMCSIKTQT LKKKKKNHSP LKYMLKYNNY PHAYCSWNLK SVTPGEKIVL
     NFTTMDLYKS SLCWYDYIEV RDGYWRKSPL LGRFCGDKVP EVLASTDSRM WIEFRSSSNW
     VGKGFAAVYE AICGGEIRKN EGQIQSPNYP DDYRPMKECV WRIMVSESYH VGLTFQAFEI
     ERHDNCAYDY LEVRDGTSEN SPLIGRFCGY DKPEDIRSTS NTLWMKFVSD GTVNKAGFAA
     NFFKEEDECA KADRGGCEQR CLNTLGSYQC ACEPGYELGP DRRSCEAACG GLLTKLNGTI
     TTPGWPKEYP PNKNCVWQVV APTQYRISMK FEFFELEGNE VCKYDYVEIW SGLSSEAKLH
     GKFCGAEVPE VITSQFNNMR IEFKSDNTVS KKGFKAHFFS DKDECSKDNG GCQHECVNTM
     GSYMCQCRNG FVLHENKHDC KEAECEQKIH SPSGLITSPN WPDKYPSRKE CTWEISATPG
     HRIKLAFSEF EIEQHQECAY DHLEVFDGET EKSPILGRLC GNRIPDPLVA TGNKMFVRFV
     SDASVQRKGF QATHSTECGG RLRAEPKPRD LYSHAQFGDN NYPGQVDCEW LLVAERGSRL
     ELSFQTFEVE EEADCGYDYV ELFDGLEPAA VGLGRFCGSG PPEEIYSIGD TVLIHFHTDD
     TINKKGFHVR YKSIRYPETS HTKN
//
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