ID G1SI61_RABIT Unreviewed; 1665 AA.
AC G1SI61;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Rho GTPase activating protein 21 {ECO:0000313|Ensembl:ENSOCUP00000002360.4};
GN Name=ARHGAP21 {ECO:0000313|Ensembl:ENSOCUP00000002360.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000002360.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000002360.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000002360.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000002360.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000002360.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Cytoplasmic
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004284}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004284}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004395}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004395}.
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DR EMBL; AAGW02059374; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02059375; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02059376; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02059377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02059378; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02059379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PaxDb; 9986-ENSOCUP00000002360; -.
DR Ensembl; ENSOCUT00000002723.4; ENSOCUP00000002360.4; ENSOCUG00000002720.4.
DR eggNOG; KOG4407; Eukaryota.
DR GeneTree; ENSGT00940000155406; -.
DR HOGENOM; CLU_001776_1_0_1; -.
DR TreeFam; TF329345; -.
DR Proteomes; UP000001811; Chromosome 16.
DR Bgee; ENSOCUG00000002720; Expressed in frontal cortex and 16 other cell types or tissues.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01253; PH_ARHGAP21-like; 1.
DR CDD; cd04395; RhoGAP_ARHGAP21; 1.
DR Gene3D; 1.20.5.220; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23175:SF16; RHO GTPASE-ACTIVATING PROTEIN 21; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 52..161
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 897..1006
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1110..1302
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1053..1089
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1311..1360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1379..1538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1559..1578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1606..1665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 866..880
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1061..1085
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1312..1329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1339..1360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1388..1419
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1451..1477
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1559..1576
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1618..1632
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1665 AA; 180843 MW; 3FDB328F60C3E13A CRC64;
MMATRRTGLP EGDGDKLKAC ETPVSKNKDG KEQSETVSPS EDEAFSWPGP KTVTLKRTPQ
GFGFTLRHFI VYPPESAVQL SYKDEENGNR GGKQGKRLEP MDTIFVKQVK EGGPAFEAGL
CTGDRIIKVN GESVIGKTYS QVIALIQNSD TALELSVMPK DEDILQVAYS QDAYLKGNEA
YSGNARNIPE PPPVCYPWLP SAPPAAAAQP AEASPADAPL SKQQTSTPGP TPPGRAYRME
IQVPPSPTDV AKSNTAVCVC NESVRSVIVP SEKAVDVLPG RGSHTGPSHR TEEVRYGANE
HTSLKAVSRA TSPPSSVPAA HRIHHAAGSR SLDPSGGLLK SGNYAGHSEG IPSDRAHAVD
SPSIAVNHYS PNSHQRIDWK NYKTYKEYID NRRLHIGCRT IQERLDSLRA ASRSTADYSQ
VAPGRAASQV RRRSTSHDRV PPAAQIRQRS VSQERLEDPV LTRYCPRSAS QGALTSPPVG
LSQHRTRSWD YLEGQGEPAE RQTPDSNGER AQASRWGGFA ERDDRRGVRE APKAFRGAHL
SVAPGAVSVE SRRVTGRGAP GAPQFKKPPL DLKALQPSRT VPTACGAPLA RGVAQDRSPL
VKVRSHSLKA PSAHAAAKPA VSQNSLVCTK DQRPVIHAHE NSVLSQQTWF RPESAPDHQA
DPAKPPSVSG APAKPAAQTS ENGAAAECEL SVSLRDVDIR AAEAGAPQPH PADGTEAVVL
REKPPSGRQT PQPLRHQSYI LAVNDQEAGS DSTCWLPNDA RREVHIKRLE ERKASSASPP
GDSLASIPFI DEPTSPSIDH DIAHISASAV ISASTSQVPC RATVPPSLTT SAPLIRRQLS
HDHDSIGPPS LDAQPTSKTE RSKSYDEVSG VASITDSQKS SEDSGSRKDS SSEVFSDAAK
EGWLHFRPLV TDKGKRVGGS IRPWKQMYVV LRGHSLYLYK DKREQTAPCE EEQPISVNAC
LIDISYSETK RKNVFRLTTS DRECLFQAED RDDMLAWIKT IQDSSNLNEE DTGVTNRDLI
SRRIKEYNSL MSKAEQLPKT PRQSLSLRQT LLGAKSEPKT QSPHSPKEEP ERKLLGKDDT
SPPKDRGMWI RGIPQIGRRK KPAATGTFGV RLDDCPPAHT NRYIPLIVDI CCKLVEERGL
EYTGIYRVPG NNAAISSMQE ELNKGMADID IQDDKWRDLN VISSLLKSFF RKLPEPLFTN
DKYADFIEAN RKEDPLDRLK TLKRLIHDLP EHHYETLKFL SAHLKTVAEN SEKNKMEPRN
LAIVFGPTLV RTSEDNMTHM VTHMPDQYKI VETLIQHHDW FFTEEGAEEP LTTVRQESTV
ESQPVPNIDH LLSNIGRTGA SPGDASDSAT SDSTKSKVTC SGEQYSRELL VTSIFAAASR
KRKKPKEKAQ PSSSEDELDS VFSKKEPGAQ GREHGRAGEA AGRTPGAPRS ASPSPEAAPW
AAGRLSPEAR SVAESRGEEA DDERSELVSE GRPPESDSEG DFPACAAPGR RDSEGSEASG
PRPAAARAHQ LIEGDTLARR KAAPTGSDGD GDAPALARNI LDGTVTSLRT QAEADFRRGV
RRRHTLGGHR DASFWKEPEL SAVTRLQPRC PAQDLSITHW LARERLRTST PDLSTPGGLD
PAPVPAPRPA PPDQVNGGDG FPGASCAAAS QPPALSGAAQ PHPCL
//
