ID G1SIU1_RABIT Unreviewed; 835 AA.
AC G1SIU1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011};
GN Name=TNNI3K {ECO:0000313|Ensembl:ENSOCUP00000002612.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000002612.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000002612.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000002612.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000002612.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000002612.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02002036; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02002037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02002038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02002039; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02002040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02002041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02002042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02002043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001191736.1; NM_001204807.1.
DR RefSeq; XP_002715966.1; XM_002715920.3.
DR AlphaFoldDB; G1SIU1; -.
DR SMR; G1SIU1; -.
DR STRING; 9986.ENSOCUP00000002612; -.
DR PaxDb; 9986-ENSOCUP00000002612; -.
DR Ensembl; ENSOCUT00000003004.4; ENSOCUP00000002612.4; ENSOCUG00000003001.4.
DR GeneID; 100533992; -.
DR KEGG; ocu:100533992; -.
DR CTD; 51086; -.
DR eggNOG; KOG0192; Eukaryota.
DR GeneTree; ENSGT00940000159131; -.
DR HOGENOM; CLU_017658_0_0_1; -.
DR InParanoid; G1SIU1; -.
DR OrthoDB; 3020493at2759; -.
DR TreeFam; TF317710; -.
DR Proteomes; UP000001811; Chromosome 13.
DR Bgee; ENSOCUG00000003001; Expressed in heart and 15 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:Ensembl.
DR GO; GO:0086069; P:bundle of His cell to Purkinje myocyte communication; IEA:Ensembl.
DR GO; GO:1903779; P:regulation of cardiac conduction; IEA:Ensembl.
DR GO; GO:0055117; P:regulation of cardiac muscle contraction; IEA:Ensembl.
DR GO; GO:0002027; P:regulation of heart rate; IEA:Ensembl.
DR CDD; cd14064; PKc_TNNI3K; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR24118:SF99; CHARON; 1.
DR PANTHER; PTHR24118; POTE ANKYRIN DOMAIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 10.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 6.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT REPEAT 100..132
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 133..165
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 169..198
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 199..231
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 269..301
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 339..371
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 463..723
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 490
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 835 AA; 92854 MW; 254655AD0D60F563 CRC64;
MGNYKSRPTQ TCTDEWKKKV SESYVTIIER LEDDLQIKDK ELTELSHIFS SDEAFSEVNL
NYRTENGLSL LHLCCICGGN KSHIRTLMLK GLRPSRLTKN GFTALHLAVY KDSAELITSL
LHSGADIQQV GYGGLTALHI ATITGHLEAA DVLLQHGANV NVQDAVFFTP LHIAAYYGHE
QITRLLLKFG ADVNVSGEVG DRPLHLASAK GFFNIAKLLM EEGSKADVNA QDNEDHVPLH
FCSRFGHHDI VKYLLQSDLA VQPHVVNIYG DTPLHLACYN GKFDVAKEII QISGTESLTK
ENIFSETAFH SACTYGKSID LVKFLLDQNV ININHQGRDG HTGLHSACYH GHIRLVQFLL
DNGADMNLVA CDPSRSSGEK DEQTCLMWAY ERGHDAIVTL LKHYKRPQEE LPCNEYSQPG
GDGSYVSVPS PLGKIKNMTK EKADVLLLRA GLPSHFHLQL SEIEFHEIIG SGSFGKVYKG
RCRNKIVAIK RYRANTYCSK SDVDMFCREV SILCQLNHPC VIQFVGACLN DPSQFAIVTQ
YISGGSLFSL LHEQKRILDL QSKLIIAVDV AKGMEYLHNL TQPIIHRDLN SHNILLYEDG
HAVVADFGES RFLQSLDEDN MTKQPGNLRW MAPEVFTQCT RYTIKADVFS YALCLWELLT
GEIPFAHLKP AAAAADMAYH HIRPPIGYSI PKPISSLLMR GWNACPEGRP EFSEVVTKLE
ECLCNIELMS PASSNSSGSL SPSSSSDCLV SRGGPGRSHV AALRSRFELE YALNARSYSA
WSQSARQCSS QGLSLEEMKR SLQYSPIDKY GYVSDPMSPM HFHSCRNSGS FEDSS
//
