ID G1SJ66_RABIT Unreviewed; 1024 AA.
AC G1SJ66;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=FERM, ARHGEF and pleckstrin domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040395};
DE AltName: Full=FERM, RhoGEF and pleckstrin domain-containing protein 1 {ECO:0000256|ARBA:ARBA00042170};
GN Name=FARP1 {ECO:0000313|Ensembl:ENSOCUP00000002761.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000002761.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000002761.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000002761.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000002761.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000002761.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Cell projection, filopodium
CC {ECO:0000256|ARBA:ARBA00004486}. Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Synapse, synaptosome
CC {ECO:0000256|ARBA:ARBA00034102}.
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DR EMBL; AAGW02021284; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02021285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02021286; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02021287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02021288; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02021289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02021290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SJ66; -.
DR Ensembl; ENSOCUT00000003177.3; ENSOCUP00000002761.3; ENSOCUG00000003174.4.
DR GeneTree; ENSGT00940000155318; -.
DR HOGENOM; CLU_012301_0_0_1; -.
DR TreeFam; TF351276; -.
DR Proteomes; UP000001811; Chromosome 8.
DR Bgee; ENSOCUG00000003174; Expressed in upper lobe of left lung and 16 other cell types or tissues.
DR ExpressionAtlas; G1SJ66; baseline.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF2; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Synapse {ECO:0000256|ARBA:ARBA00022599};
KW Synaptosome {ECO:0000256|ARBA:ARBA00022599}.
FT DOMAIN 1..285
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 518..709
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 738..835
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 911..1008
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 326..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 842..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..405
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1024 AA; 115854 MW; F92B5D5A18BCAE46 CRC64;
MGEIEQKPTP GSRLGAPENS GISTLEHGQK PPPTPSGKLM SIKIQMLDDT QEAFEVPVWL
DLLKPIVKQI RRPKHVVVKF VVKFFPPDHT QLQEELTRYL FALQVKQDLA QGRLTCNDTS
AALLISHIVQ SEIGDFDEAL DREHLAKNKY IPQQDALEDK IVEFHHNHIG QTPAESDFQL
LEIARRLEMY GIRLHPAKDR EGTKINLAVA NTGILVFQGF TKINAFNWAK VRKLSFKRKR
FLIKLRPDAN SSYQDTLEFL MASRDFCKSF WKICVEHHAF FRLFEEPKPK PKAVLFSRGS
SFRFSGRTQK QVLDYVKEGG HKKVQFERKH SKIHSIRSLA TQPSETDSEV PKQSPQSASL
TFGEGADSPR GQSRQQGKEL KVAAPSAAAP APTEDPRPQP GPQASPALQR SPAGNRQADG
ASPAPPEEEE EVLKDSTQQS KAQPPQPCTG SLTGSPHLSE LSITSQGGAG PTNVTLSPNL
SPDTKQASPL ISPLLNDQAC PRTDDEEESR RKRFPTDKAY FIAKEVSTTE RTYLKDLEVI
TSWFQSTVSK EDSMPETLKS LIFPNFEPLH KFHTNFLKEI EQRLALWEGR SNAQVKGDYQ
RIGDVLLRNI QGMKHLAAHL WRHSEALEAL ENGLKNSRRL ESFCRDFELQ KVCYLPLNTF
LLRPLHRLMH YRQVLERLCK HHPPSHADFR DCRAALAEIT EMVAQLHGTM IKMENFQKLH
ELKKDLIGID NLVIPGREFI RLGSLSKLSG KGLQQRMFFL FNDVLLYTSR GLTASNQFKV
HGQLPLYGMT IEEGEAEWGL PHCLTLRGQR QSIIVAASSR AEMEKWVEDI QMAIDLAEKS
SCPSPELLAS SPPDNKSPDE ATAADQESED DLSASRTSLE RQAPHRGNTM VHVCWHRNTS
VSMVDFSIAV ENQLSGNLLR KFKNSNGWQK LWVVFTNFCL FFYKSHQDNH PLASLPLLGY
SLTIPSEAEN IHKDHVFKLH FKSHVYYFRA ESEYTFERWM EVIRSATSSA SRAPSASHKD
SHAY
//
