ID   G1SJC5_RABIT            Unreviewed;       504 AA.
AC   G1SJC5;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 2.
DT   27-MAR-2024, entry version 61.
DE   RecName: Full=SH3 domain-containing protein {ECO:0000259|SMART:SM00326};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000002830.3, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000002830.3, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000002830.3}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000002830.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   STRING; 9986.ENSOCUP00000002830; -.
DR   PaxDb; 9986-ENSOCUP00000002830; -.
DR   Ensembl; ENSOCUT00000003260.3; ENSOCUP00000002830.3; ENSOCUG00000003260.3.
DR   eggNOG; KOG4348; Eukaryota.
DR   GeneTree; ENSGT00940000160627; -.
DR   HOGENOM; CLU_740918_0_0_1; -.
DR   InParanoid; G1SJC5; -.
DR   TreeFam; TF338545; -.
DR   Proteomes; UP000001811; Unplaced.
DR   Bgee; ENSOCUG00000003260; Expressed in testis and 15 other cell types or tissues.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443}.
FT   DOMAIN          68..112
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|SMART:SM00326"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          114..504
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        156..183
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..274
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        430..444
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        464..478
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        482..504
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   504 AA;  54180 MW;  6AD9D8DA38F19F91 CRC64;
     XCKSELQLQP GAGGRTDPGI WGDCGNDKGG LGNSDMPSIC PGAQRPPKLS SLAYDSPPDY
     LRTVSHPETY RVLFDYQPEA PDELTTEDKG WWLGECQGRR GVFPDNFVLP PPAVKKLGPC
     KVASREPAPV KEPKKLVPKT FLPMVKKPVT SPPGPSKTKP SWTASGDSQK RPSRASGTNG
     SFLGGGPSCP GRKRSKTQPP RQRSASSQGE ERSSLAKAPA MTRTPTPDKN ATPEKTPSPE
     KMPAPDQVPD PAQTLPQEDQ TPTPEETGTL GDPTPEQTPA LDEASSPEVV FPADDVPATE
     VPPEQEAPDP VAAQGDEAPT LEQVLSEVVI SPGAHPQLHH FSPEEALWVK SLVAKEPESQ
     EMAHMPDEPS PPAQCSERPL GKRDGDSSRG SEPQPQTGPM PAPEKARPPE EATALLVEST
     LQEEVPPKEQ LAPQRQEEEA APARQRPHPS QQTPDPQETP TVHPPEGGRD RGDLVTLKDE
     VQSLRTALQQ MGDSRHAQTQ TQTH
//